ChEMBL ligand: CHEMBL2104993 (Brintellix, LUAA21004, LU AA21004, LU-AA21004, Vortioxetine)
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] There should be some charts here, you may need to enable JavaScript!
SERT in Human [GtoPdb: 928] [UniProtKB: P31645] SERT/Serotonin transporter in Rat [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] There should be some charts here, you may need to enable JavaScript!
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222] There should be some charts here, you may need to enable JavaScript!
5-HT1D receptor in Rat [GtoPdb: 3] [UniProtKB: P28565] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] There should be some charts here, you may need to enable JavaScript!
5-HT5A receptor in Human [GtoPdb: 10] [UniProtKB: P47898] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406] There should be some charts here, you may need to enable JavaScript!
5-HT3A in Human [GtoPdb: 379] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb	-	-	7.82	pKi	15	nM	Ki	J Med Chem (2011) 54: 3206-21 [PMID:21486038]
ChEMBL	Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method	B	8.02	pKi	9.5	nM	Ki	Bioorg Med Chem Lett (2017) 27: 5420-5423 [PMID:29138029]
ChEMBL	Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by TopCount scintillation counting method	B	8.02	pKi	9.5	nM	Ki	Eur J Med Chem (2018) 144: 701-715 [PMID:29291438]
ChEMBL	Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counting method	B	8.02	pKi	9.5	nM	Ki	Bioorg Med Chem Lett (2019) 29: 126703-126703 [PMID:31627993]
ChEMBL	Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counting method	B	8.02	pKi	9.5	nM	Ki	Bioorg Med Chem Lett (2019) 29: 126769-126769 [PMID:31699607]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
GtoPdb	-	-	6.35	pKi	450	nM	Ki	J Med Chem (2011) 54: 3206-21 [PMID:21486038]
ChEMBL	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	B	7.59	pKi	26	nM	Ki	Bioorg Med Chem Lett (2017) 27: 5420-5423 [PMID:29138029]
ChEMBL	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2018) 144: 701-715 [PMID:29291438]
ChEMBL	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	B	7.59	pKi	26	nM	Ki	Bioorg Med Chem Lett (2019) 29: 126703-126703 [PMID:31627993]
ChEMBL	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	B	7.59	pKi	26	nM	Ki	Bioorg Med Chem Lett (2019) 29: 126769-126769 [PMID:31699607]
SERT in Human [GtoPdb: 928] [UniProtKB: P31645]
GtoPdb	-	-	8.8	pKi	1.6	nM	Ki	J Med Chem (2011) 54: 3206-21 [PMID:21486038]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL	Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting method	B	8.54	pIC50	2.9	nM	IC50	Bioorg Med Chem Lett (2017) 27: 5420-5423 [PMID:29138029]
ChEMBL	Inhibition of [3H]serotonin reuptake in rat brain synaptosomes SERT after 15 mins by TopCount scintillation counting method	B	8.54	pIC50	2.9	nM	IC50	Eur J Med Chem (2018) 144: 701-715 [PMID:29291438]
ChEMBL	Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting method	B	8.54	pIC50	2.9	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126703-126703 [PMID:31627993]
ChEMBL	Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting method	B	8.54	pIC50	2.9	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126769-126769 [PMID:31699607]
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb	-	-	7.48	pKi	33	nM	Ki	J Med Chem (2011) 54: 3206-21 [PMID:21486038]
5-HT1D receptor in Rat [GtoPdb: 3] [UniProtKB: P28565]
GtoPdb	-	-	5.4	pIC50	4000	nM	IC50	J Med Chem (2004) 47: 4684-92 [PMID:15341484]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb	-	-	6.74	pKi	180	nM	Ki	J Med Chem (2011) 54: 3206-21 [PMID:21486038]
5-HT5A receptor in Human [GtoPdb: 10] [UniProtKB: P47898]
GtoPdb	-	-	6.66	pKi	220	nM	Ki	J Med Chem (2011) 54: 3206-21 [PMID:21486038]
5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406]
GtoPdb	-	-	6.48	pKi	330	nM	Ki	J Med Chem (2011) 54: 3206-21 [PMID:21486038]
5-HT3A in Human [GtoPdb: 379]
GtoPdb	-	-	8.43	pKi	3.7	nM	Ki	J Med Chem (2011) 54: 3206-21 [PMID:21486038]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]