- Guide to PHARMACOLOGY
Synonyms: Fanapt® | HP-873
iloperidone is an approved drug (FDA (2009))
Compound class: Synthetic organic
Comment: Iloperidone is an atypical antipsychotic drug.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Measuring displacement of [3H]spiperone from rat cortex provides an IC50 value for iloperidone of 9nM . The ratio of IC50 values of dopamine D2 binding over 5-HT2 binding is 12.2. When >1, this ratio indicates the potential efficacy of a drug as an atypical antipsychotic .
We have been unable to find open-access data for iloperidone at the human dopamine D2 and serotonin 5-HT2 receptors to substantiate the drug's MMOA.
|Selectivity at GPCRs|
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