ChEMBL ligand: CHEMBL14376 (Fanapt, HP 873, HP-873, Iloperidona, Iloperidone)
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Rat [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Mouse [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
M3 receptor/Muscarinic acetylcholine receptor M3 in Rat [ChEMBL: CHEMBL320] [GtoPdb: 15] [UniProtKB: P08483] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908] 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Mouse [ChEMBL: CHEMBL3737] [GtoPdb: 1] [UniProtKB: Q64264] 5-HT1A receptor in Rat [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!
Serotonin 2a (5-HT2a) receptor in Bovine [ChEMBL: CHEMBL3446] [UniProtKB: Q75Z89] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406] 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969] 5-HT7 receptor in Rat [GtoPdb: 12] [UniProtKB: P32305] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909]
ChEMBL	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (1995) 38: 1119-1131 [PMID:7707315]
D1 receptor/Dopamine D1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616]
ChEMBL	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	B	6.12	pIC50	750	nM	IC50	J Med Chem (1995) 38: 1119-1131 [PMID:7707315]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Binding affinity against Dopamine receptor D2 was determined using [ [3H]-spiperone radioligand	B	6.96	pIC50	110	nM	IC50	J Med Chem (1995) 38: 1119-1131 [PMID:7707315]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.	B	6.96	pIC50	110	nM	IC50	J Med Chem (1995) 38: 1119-1131 [PMID:7707315]
GtoPdb	Measuring displacement of [3H]spiperone from rat striatum.	-	6.96	pIC50	110	nM	IC50	J Med Chem (1995) 38: 1119-31 [PMID:7707315]
M3 receptor/Muscarinic acetylcholine receptor M3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL320] [GtoPdb: 15] [UniProtKB: P08483]
ChEMBL	Binding affinity against Muscarinic acetylcholine receptor using [3H]quinuclidinyl benzilate	B	6	pIC50	>1000	nM	IC50	J Med Chem (1995) 38: 1119-1131 [PMID:7707315]
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb	-	-	7	pKi	-	-	-	Neuropsychopharmacology (2001) 25: 904-14 [PMID:11750183]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3737] [GtoPdb: 1] [UniProtKB: Q64264]
ChEMBL	Binding affinity against 5-hydroxytryptamine 1A receptor was determined using [3H]-8-OH-DPAT radioligand	B	6.68	pIC50	210	nM	IC50	J Med Chem (1995) 38: 1119-1131 [PMID:7707315]
5-HT1A receptor in Rat [GtoPdb: 1] [UniProtKB: P19327]
GtoPdb	-	-	6.8	pKi	-	-	-	Eur J Pharmacol (1996) 317: 417-23 [PMID:8997630]
Serotonin 2a (5-HT2a) receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3446] [UniProtKB: Q75Z89]
ChEMBL	Binding affinity against 5-hydroxytryptamine 2 receptor was determined using [ [3H]spiperone radioligand	B	8.05	pIC50	9	nM	IC50	J Med Chem (1995) 38: 1119-1131 [PMID:7707315]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Binding affinity against sigma receptor using [3H]-( +)-SKF10,047 radioligand	B	7.19	pIC50	64	nM	IC50	J Med Chem (1995) 38: 1119-1131 [PMID:7707315]
5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406]
GtoPdb	-	-	7.2	pKi	-	-	-	Neuropsychopharmacology (2001) 25: 904-14 [PMID:11750183]
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
GtoPdb	-	-	7.4	pKi	-	-	-	Eur J Pharmacol (1996) 317: 417-23 [PMID:8997630]
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969]
GtoPdb	-	-	7	pKi	-	-	-	Neuropsychopharmacology (2001) 25: 904-14 [PMID:11750183]
5-HT7 receptor in Rat [GtoPdb: 12] [UniProtKB: P32305]
GtoPdb	-	-	7.7	pKi	-	-	-	Eur J Pharmacol (1996) 317: 417-23 [PMID:8997630]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]