ChEMBL ligand: CHEMBL14376 (Fanapt, HP 873, HP-873, Iloperidone)
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Rat [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Mouse [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
M3 receptor/Muscarinic acetylcholine receptor M3 in Rat [ChEMBL: CHEMBL320] [GtoPdb: 15] [UniProtKB: P08483] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908] 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Mouse [ChEMBL: CHEMBL3737] [GtoPdb: 1] [UniProtKB: Q64264] 5-HT1A receptor in Rat [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!
Serotonin 2a (5-HT2a) receptor in Bovine [ChEMBL: CHEMBL3446] [UniProtKB: Q75Z89] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406] 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969] 5-HT7 receptor in Rat [GtoPdb: 12] [UniProtKB: P32305] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909]
ChEMBL	Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand	B	9.4	pIC50	0.4	nM	IC50	J. Med. Chem. (1995) 38: 1119-1131 [PMID:7707315]
D1 receptor/Dopamine D1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616]
ChEMBL	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	B	6.12	pIC50	750	nM	IC50	J. Med. Chem. (1995) 38: 1119-1131 [PMID:7707315]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Binding affinity against Dopamine receptor D2 was determined using [ [3H]-spiperone radioligand	B	6.96	pIC50	110	nM	IC50	J. Med. Chem. (1995) 38: 1119-1131 [PMID:7707315]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.	B	6.96	pIC50	110	nM	IC50	J. Med. Chem. (1995) 38: 1119-1131 [PMID:7707315]
GtoPdb	Measuring displacement of [3H]spiperone from rat striatum.	-	6.96	pIC50	110	nM	IC50	J Med Chem (1995) 38: 1119-31 [PMID:7707315]
M3 receptor/Muscarinic acetylcholine receptor M3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL320] [GtoPdb: 15] [UniProtKB: P08483]
ChEMBL	Binding affinity against Muscarinic acetylcholine receptor using [3H]quinuclidinyl benzilate	B	6	pIC50	>1000	nM	IC50	J. Med. Chem. (1995) 38: 1119-1131 [PMID:7707315]
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb	-	-	7	pKi	-	-	-	Neuropsychopharmacology (2001) 25: 904-14 [PMID:11750183]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3737] [GtoPdb: 1] [UniProtKB: Q64264]
ChEMBL	Binding affinity against 5-hydroxytryptamine 1A receptor was determined using [3H]-8-OH-DPAT radioligand	B	6.68	pIC50	210	nM	IC50	J. Med. Chem. (1995) 38: 1119-1131 [PMID:7707315]
5-HT1A receptor in Rat [GtoPdb: 1] [UniProtKB: P19327]
GtoPdb	-	-	6.8	pKi	-	-	-	Eur J Pharmacol (1996) 317: 417-23 [PMID:8997630]
Serotonin 2a (5-HT2a) receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3446] [UniProtKB: Q75Z89]
ChEMBL	Binding affinity against 5-hydroxytryptamine 2 receptor was determined using [ [3H]spiperone radioligand	B	8.05	pIC50	9	nM	IC50	J. Med. Chem. (1995) 38: 1119-1131 [PMID:7707315]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Binding affinity against sigma receptor using [3H]-( +)-SKF10,047 radioligand	B	7.19	pIC50	64	nM	IC50	J. Med. Chem. (1995) 38: 1119-1131 [PMID:7707315]
5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406]
GtoPdb	-	-	7.2	pKi	-	-	-	Neuropsychopharmacology (2001) 25: 904-14 [PMID:11750183]
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
GtoPdb	-	-	7.4	pKi	-	-	-	Eur J Pharmacol (1996) 317: 417-23 [PMID:8997630]
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969]
GtoPdb	-	-	7	pKi	-	-	-	Neuropsychopharmacology (2001) 25: 904-14 [PMID:11750183]
5-HT7 receptor in Rat [GtoPdb: 12] [UniProtKB: P32305]
GtoPdb	-	-	7.7	pKi	-	-	-	Eur J Pharmacol (1996) 317: 417-23 [PMID:8997630]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]