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ChEMBL ligand: CHEMBL14376 (Fanapt, HP 873, HP-873, Iloperidone) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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α2A-adrenoceptor/Alpha-2a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909] | ||||||||
ChEMBL | Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligand | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (1995) 38: 1119-1131 [PMID:7707315] |
D1 receptor/Dopamine D1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616] | ||||||||
ChEMBL | Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand | B | 6.12 | pIC50 | 750 | nM | IC50 | J Med Chem (1995) 38: 1119-1131 [PMID:7707315] |
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Binding affinity against Dopamine receptor D2 was determined using [ [3H]-spiperone radioligand | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (1995) 38: 1119-1131 [PMID:7707315] |
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
ChEMBL | Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum. | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (1995) 38: 1119-1131 [PMID:7707315] |
GtoPdb | Measuring displacement of [3H]spiperone from rat striatum. | - | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (1995) 38: 1119-31 [PMID:7707315] |
M3 receptor/Muscarinic acetylcholine receptor M3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL320] [GtoPdb: 15] [UniProtKB: P08483] | ||||||||
ChEMBL | Binding affinity against Muscarinic acetylcholine receptor using [3H]quinuclidinyl benzilate | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (1995) 38: 1119-1131 [PMID:7707315] |
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
GtoPdb | - | - | 7 | pKi | - | - | - | Neuropsychopharmacology (2001) 25: 904-14 [PMID:11750183] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3737] [GtoPdb: 1] [UniProtKB: Q64264] | ||||||||
ChEMBL | Binding affinity against 5-hydroxytryptamine 1A receptor was determined using [3H]-8-OH-DPAT radioligand | B | 6.68 | pIC50 | 210 | nM | IC50 | J Med Chem (1995) 38: 1119-1131 [PMID:7707315] |
5-HT1A receptor in Rat [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
GtoPdb | - | - | 6.8 | pKi | - | - | - | Eur J Pharmacol (1996) 317: 417-23 [PMID:8997630] |
Serotonin 2a (5-HT2a) receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3446] [UniProtKB: Q75Z89] | ||||||||
ChEMBL | Binding affinity against 5-hydroxytryptamine 2 receptor was determined using [ [3H]spiperone radioligand | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (1995) 38: 1119-1131 [PMID:7707315] |
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
ChEMBL | Binding affinity against sigma receptor using [3H]-( +)-SKF10,047 radioligand | B | 7.19 | pIC50 | 64 | nM | IC50 | J Med Chem (1995) 38: 1119-1131 [PMID:7707315] |
5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
GtoPdb | - | - | 7.2 | pKi | - | - | - | Neuropsychopharmacology (2001) 25: 904-14 [PMID:11750183] |
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] | ||||||||
GtoPdb | - | - | 7.4 | pKi | - | - | - | Eur J Pharmacol (1996) 317: 417-23 [PMID:8997630] |
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
GtoPdb | - | - | 7 | pKi | - | - | - | Neuropsychopharmacology (2001) 25: 904-14 [PMID:11750183] |
5-HT7 receptor in Rat [GtoPdb: 12] [UniProtKB: P32305] | ||||||||
GtoPdb | - | - | 7.7 | pKi | - | - | - | Eur J Pharmacol (1996) 317: 417-23 [PMID:8997630] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]