IL-6   Click here for help

GtoPdb Ligand ID: 4998

Synonyms: B-cell stimulatory factor 2 | CTL differentiation factor | hybridoma growth factor | interferon β2 | interleukin-6
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-6 is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. It is the originating member of a family of related cytokines that include IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine factor 1/B-cell stimulating factor 3 (NNT-1), neuropoietin (NPN), IL-27, and IL-31 [14]. IL-6 is produced by T and B cells, macrophages, dendritic cells, and non-immune cells such as fibroblasts, endothelial cells, glial cells, keratinocytes, and placental syncytio- and extravillous trophoblasts.
The receptors for these cytokines (except IL-31) share a common signal transducing subunit gp130 (IL6ST).
IL-6 is a critical regulator of the immune system and has been widely implicated in autoimmune disease, infection responses and in the regulation of metabolic, regenerative, and neural processes.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Natural/Endogenous Targets
Target
Interleukin-6 receptor
Interleukin-6 receptor, α subunit
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-6 receptor, α subunit Primary target of this compound Ligand is endogenous in the given species Hs Agonist Agonist 9.4 pKd - 13
⤷ pKd 9.4 (Kd 4.4x10-10 M) IL6R) expressed stably in murine NIH/3T3 fibroblasts.exhibited a single class of binding sites for 125I-labeled recombinant human interleukin-6 (125I-rhIL-6) (Kd = 440 pM, 20,000 receptors per cell). [13]
Interleukin-6 receptor Primary target of this compound Ligand is endogenous in the given species Hs Agonist Agonist 9.4 pKd - 13
⤷ pKd 9.4 (Kd 4.4x10-10 M) Murine NIH/3T3 fibroblasts with human IL6R exhibited a single class of binding sites for 125I-labeled recombinant human interleukin-6 (125I-rhIL-6) (Kd = 440 pM, 20,000 receptors per cell). [13]
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
sirukumab Peptide Primary target of this compound Hs Antibody Binding 13.4 pKd - 2
⤷ pKd 13.4 (Kd 3.7x10-14 M) [2]
ziltivekimab Peptide Hs Antibody Binding >11.0 pKd - 5
⤷ pKd >11.0 (Kd <1x10-11 M) [5]
Description: Binding affinity for the CAT6001 parent of MEDI5117- both share the same anti-IL-6 binding domain. Binding in the SPR assay reached the limit of the assay's sensitivity.
olokizumab Peptide Hs Antibody Binding 11.0 pKd - 15
⤷ pKd 11.0 (Kd 1x10-11 M) [15]
Description: Binding affinity determined in a Biacore SPR assay with immobilised antibody and hIL-6 in the solution phase.
clazakizumab Peptide Primary target of this compound Hs Antibody Binding >10.3 pKd - 7
⤷ pKd >10.3 (Kd <5x10-11 M) [7]
siltuximab Peptide Approved drug Primary target of this compound Hs Antibody Binding 10.2 pKd - 9
⤷ pKd 10.2 (Kd 5.7x10-11 M) [9]
olamkicept Peptide Hs None Binding 8.4 pKd - 12
⤷ pKd 8.4 (Kd 4.2x10-9 M) [12]
Description: Binding of hIL-6 to immobilized sgp130-Fc (olamkicept).