olamkicept   Click here for help

GtoPdb Ligand ID: 9729

Synonyms: FE 999301 | FE-301 | FE-999301 | TJ301
Immunopharmacology Ligand
Compound class: Peptide or derivative
Comment: Olamkicept is a recombinant protein that fuses the extracellular domain of the signal transducing subunit of the IL-6 receptor, IL-6Rβ (glycoprotein 130, gp130), to a human IgG Fc fragment [3]. The full construct is a dimer of covalently linked identical peptide chains. Mechanistically olamkicept acts as an inhibitor of the IL-6 signalling pathway. Olamkicept inhibits trans signalling by the soluble IL-6 receptor (sIL-6R) [1], a mechanism that is involved in human inflammatory and autoimmune diseases [2]. It is hypothesised to be clinically effective in reducing disease signs and symptoms whilst not being detrimental to the role of IL-6 in the acute immune response to infection.
Classification Click here for help
Compound class Peptide or derivative
International Nonproprietary Names Click here for help
INN number INN
10311 olamkicept
Synonyms Click here for help
FE 999301 | FE-301 | FE-999301 | TJ301
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 730
Other databases
GtoPdb PubChem SID 354702205
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