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Target id: 1708
Nomenclature: Interleukin-6 receptor, α subunit
Abbreviated Name: IL6R
Systematic Nomenclature: interleukin 6 receptor
Family: IL-6 receptor family
Quaternary Structure: Complexes |
Interleukin-6 receptor |
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 468 | 1q21.3 | IL6R | interleukin 6 receptor | |
Mouse | 1 | 460 | 3 39.19 cM | Il6ra | interleukin 6 receptor, alpha | |
Rat | 1 | 462 | 2q34 | Il6r | interleukin 6 receptor |
Previous and Unofficial Names |
CD126 | IL-6R subunit alpha | interleukin 6 receptor |
Database Links | |
Alphafold | P08887 (Hs), P22272 (Mm), P22273 (Rn) |
CATH/Gene3D | 2.60.40.10 |
ChEMBL Target | CHEMBL2364155 (Hs), CHEMBL4289 (Rn) |
DrugBank Target | P08887 (Hs) |
Ensembl Gene | ENSG00000160712 (Hs), ENSMUSG00000027947 (Mm), ENSRNOG00000020811 (Rn) |
Entrez Gene | 3570 (Hs), 16194 (Mm), 24499 (Rn) |
Human Protein Atlas | ENSG00000160712 (Hs) |
KEGG Gene | hsa:3570 (Hs), mmu:16194 (Mm), rno:24499 (Rn) |
OMIM | 147880 (Hs) |
Pharos | P08887 (Hs) |
UniProtKB | P08887 (Hs), P22272 (Mm), P22273 (Rn) |
Wikipedia | IL6R (Hs) |
Selected 3D Structures | |||||||||||
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Natural/Endogenous Ligands |
IL-6 {Sp: Human} |
Download all structure-activity data for this target as a CSV file
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Antibodies | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
IL6R polymorphisms are associated with asthma risk [1]. |
Immuno Process Associations | ||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||||||||
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Biologically Significant Variants | ||||||||||||
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General Comments |
The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer glycoprotein 130 (gp130 from the IL6ST gene). |
1. Ferreira MA, Matheson MC, Duffy DL, Marks GB, Hui J, Le Souëf P, Danoy P, Baltic S, Nyholt DR, Jenkins M et al.. (2011) Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet, 378 (9795): 1006-14. [PMID:21907864]
2. Garbers C, Monhasery N, Aparicio-Siegmund S, Lokau J, Baran P, Nowell MA, Jones SA, Rose-John S, Scheller J. (2014) The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. Biochim Biophys Acta, 1842 (9): 1485-94. [PMID:24878322]
3. Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE et al.. (2012) The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol, 130 (2): 510-5.e1. [PMID:22554704]
4. Revez JA, Bain L, Chapman B, Powell JE, Jansen R, Duffy DL, Tung JY, AAGC Collaborators, Penninx BW, Visscher PM et al.. (2013) A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk. Genes Immun, 14 (7): 441-6. [PMID:23945879]
5. Rose-John S, Hipp E, Lenz D, Legrés LG, Korr H, Hirano T, Kishimoto T, Heinrich PC. (1991) Structural and functional studies on the human interleukin-6 receptor. Binding, cross-linking, internalization, and degradation of interleukin-6 by fibroblasts transfected with human interleukin-6-receptor cDNA. J Biol Chem, 266 (6): 3841-6. [PMID:1995637]
6. Stevens S, Huang TT, Martin JH, Fairhurst JL, Rafique A, Smith E, Pobursky KJ, Papadopoulos NJ, Fandl JP, Chen G et al.. (2009) High affinity antibodies to human IL-6 receptor. Patent number: US7582298. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 02/06/2006. Publication date: 01/09/2009.
7. Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ. (2002) Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain. Proc Natl Acad Sci USA, 99 (25): 15959-64. [PMID:12461182]
IL-6 receptor family: Interleukin-6 receptor, α subunit. Last modified on 05/10/2016. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1708.