IL-11   Click here for help

GtoPdb Ligand ID: 4976

Synonyms: interleukin-11
Immunopharmacology Ligand
Comment: IL-11 is a member of the IL-6-type cytokine family. The recombinant form of human IL-11 is an approved drug with INN oprelvekin.
Species: Human
Bioactivity Comments
The biological effects of IL-11 depend upon the cellular microenvironment [1]. Biological functions include regulation of cellular proliferation and differentiation and progression of several carcinomas. In mice IL-11 is essential for sucessful embryonic implantation and development, and decidualization of endometrial stroma cells. In humans, deficient IL-11 production is related to a decreased fertility rate.
Natural/Endogenous Targets
Interleukin-11 receptor
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-11 receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -