- Guide to PHARMACOLOGY
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-11 is a member of the IL-6-type cytokine family. The recombinant form of human IL-11 is an approved drug with INN oprelvekin.
|The biological effects of IL-11 depend upon the cellular microenvironment . Biological functions include regulation of cellular proliferation and differentiation and progression of several carcinomas. In mice IL-11 is essential for sucessful embryonic implantation and development, and decidualization of endometrial stroma cells. In humans, deficient IL-11 production is related to a decreased fertility rate.|
|Selectivity at catalytic receptors|
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