TRPM6
|
|
|
Hs |
Channel blocker |
Antagonist |
- |
- |
1x10-7 - 1x10-5 |
10 |
|
⤷ |
Conc range: 1x10-7 - 1x10-5 M
[10]
Voltage:
-120.0 – -20.0 mV
|
TRPV4
|
|
|
Mm |
Channel blocker |
Antagonist |
- |
- |
1x10-6 |
11 |
|
⤷ |
Conc range: 1x10-6 M
[11]
Voltage:
0.0 mV
|
TRPM6
|
|
|
Hs |
Channel blocker |
- |
7.0 |
pIC50 |
- |
|
|
⤷ |
pIC50
7.0
(IC50 1x10-7 M)
Voltage:
-120.0 mV
|
TRPV1
|
|
|
Hs |
Channel blocker |
Antagonist |
7.0 |
pIC50 |
- |
6 |
|
⤷ |
pIC50
7.0
[6]
Voltage:
-60.0 mV
|
TRPV5
|
|
|
Oc |
Channel blocker |
Inhibition |
6.9 |
pIC50 |
- |
8 |
|
⤷ |
pIC50
6.9
(IC50 1.11x10-7 M)
[8]
Voltage:
-150.0 – 100.0 mV
|
TRPV5
|
|
|
Hs |
Channel blocker |
- |
6.9 |
pIC50 |
- |
|
|
⤷ |
pIC50
6.9
(IC50 1.21x10-7 M)
|
TRPV1
|
|
|
Hs |
Channel blocker |
- |
6.7 – 7.0 |
pIC50 |
- |
|
|
⤷ |
pIC50
6.7 – 7.0
(IC50 2.2x10-7 – 9x10-8 M)
|
TRPV1
|
|
|
Rn |
Channel blocker |
Antagonist |
6.7 |
pIC50 |
- |
6 |
|
⤷ |
pIC50
6.7
[6]
Voltage:
-60.0 mV
|
TRPV4
|
|
|
Rn |
Channel blocker |
Inhibition |
6.7 |
pIC50 |
- |
2 |
|
⤷ |
pIC50
6.7
[2]
|
TRPV2
|
|
|
Hs |
Channel blocker |
- |
6.2 |
pIC50 |
- |
|
|
⤷ |
pIC50
6.2
(IC50 6x10-7 M)
|
TRPV2
|
|
|
Mm |
Channel blocker |
Antagonist |
6.2 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
6.2
[1]
Voltage:
-40.0 mV
|
K2P9.1
|
|
|
N/A |
Channel blocker |
- |
6.2 |
pIC50 |
- |
|
|
⤷ |
pIC50
6.2
|
TRPV3
|
|
|
Mm |
Channel blocker |
Inhibition |
6.0 |
pIC50 |
- |
9 |
|
⤷ |
pIC50
6.0
[9]
Description: Patch clamp electrophysiology
|
TRPA1
|
|
|
Mm |
Channel blocker |
Inhibition |
5.5 |
pIC50 |
- |
7 |
|
⤷ |
pIC50
5.5
(IC50 3.55x10-6 M)
[7]
Voltage:
-80.0 mV
|
CatSper1
|
|
|
Mm |
Channel blocker |
Inhibition |
5.0 |
pIC50 |
- |
5 |
|
⤷ |
pIC50
5.0
(IC50 1x10-5 M)
[5]
Description: Whole cell patch clamp
|
CatSper2
|
|
|
Mm |
Channel blocker |
Antagonist |
5.0 |
pIC50 |
- |
4 |
|
⤷ |
pIC50
5.0
(IC50 1x10-5 M)
[4]
Description: Whole cell patch clamp.
|
CatSper3
|
|
|
Mm |
Channel blocker |
Antagonist |
5.0 |
pIC50 |
- |
5 |
|
⤷ |
pIC50
5.0
(IC50 1x10-5 M)
[5]
Description: Whole cell patch clamp electrophysiology.
|
CatSper4
|
|
|
Mm |
Channel blocker |
Antagonist |
5.0 |
pIC50 |
- |
5 |
|
⤷ |
pIC50
5.0
(IC50 1x10-5 M)
[5]
Description: Whole cell patch clamp electrophysiology.
|
TRPV6
|
|
|
Mm |
Channel blocker |
Antagonist |
5.0 |
pIC50 |
- |
3 |
|
⤷ |
pIC50
5.0
(IC50 9x10-6 M)
[3]
Voltage:
-80.0 mV
|
K2P9.1
|
|
|
Hs |
Inhibitor |
- |
- |
- |
- |
|
|
⤷ |
|
RyR1
|
|
|
Hs |
Channel blocker |
- |
- |
- |
- |
|
|
⤷ |
|
RyR2
|
|
|
Hs |
Channel blocker |
- |
- |
- |
- |
|
|
⤷ |
|
RyR3
|
|
|
Hs |
Channel blocker |
- |
- |
- |
- |
|
|
⤷ |
|