AZD1480   Click here for help

GtoPdb Ligand ID: 5933

Synonyms: AZD 1480 | AZD-1480
PDB Ligand
Compound class: Synthetic organic
Comment: AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 [2]. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 104.3
Molecular weight 348.1
XLogP 2.3
No. Lipinski's rules broken 0
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Canonical SMILES Fc1cnc(nc1)C(Nc1ncc(c(n1)Nc1[nH]nc(c1)C)Cl)C
Isomeric SMILES Fc1cnc(nc1)[C@@H](Nc1ncc(c(n1)Nc1[nH]nc(c1)C)Cl)C
InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
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Molecular structure representations generated using Open Babel