AZD1480 [Ligand Id: 5933] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1231124 (Azd 1480, Azd-1480, AZD1480, AZD-1480)
  • neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
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  • signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763]
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  • Signal transducer and activator of transcription 5A in Human [ChEMBL: CHEMBL5403] [UniProtKB: P42229]
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  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
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  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
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  • Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
ChEMBL Inhibition of TrkA B 8.52 pIC50 3 nM IC50 J. Med. Chem. (2011) 54: 262-276 [PMID:21138246]
signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763]
ChEMBL Inhibition of Stat3 phosphorylation in human HEL cells after 1 hr by Western blotting B 7.1 pIC50 80 nM IC50 J. Med. Chem. (2011) 54: 262-276 [PMID:21138246]
ChEMBL Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blotting B 7.64 pIC50 23 nM IC50 J. Med. Chem. (2011) 54: 262-276 [PMID:21138246]
Signal transducer and activator of transcription 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5403] [UniProtKB: P42229]
ChEMBL Inhibition of Stat5 phosphorylation in human HEL cells after 1 hr by Western blotting B 7.39 pIC50 41 nM IC50 J. Med. Chem. (2011) 54: 262-276 [PMID:21138246]
ChEMBL Inhibition of Stat5 phosphorylation in human SET2 cells after 1 hr by Western blotting B 7.6 pIC50 25 nM IC50 J. Med. Chem. (2011) 54: 262-276 [PMID:21138246]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL Inhibition of JAK2 using 5 mM of ATP B 7.24 pIC50 58 nM IC50 J. Med. Chem. (2011) 54: 262-276 [PMID:21138246]
GtoPdb - - 8.1 pIC50 8 nM IC50 J Biol Chem (2008) 283: 32334-43 [PMID:18775810]
ChEMBL Inhibition of JAK2 using Km ATP concentration B 8.52 pIC50 <3 nM IC50 J. Med. Chem. (2011) 54: 262-276 [PMID:21138246]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
GtoPdb - - 5.44 pIC50 3630 nM IC50 J Biol Chem (2008) 283: 32334-43 [PMID:18775810]
ChEMBL Inhibition of JAK3 using 5 mM of ATP B 5.87 pIC50 1360 nM IC50 J. Med. Chem. (2011) 54: 262-276 [PMID:21138246]
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb - - 8.52 pIC50 <3 nM IC50 J Med Chem (2011) 54: 262-76 [PMID:21138246]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]