AZD1480   Click here for help

GtoPdb Ligand ID: 5933

Synonyms: AZD 1480 | AZD-1480
PDB Ligand
Compound class: Synthetic organic
Comment: AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 [2]. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 104.3
Molecular weight 348.1
XLogP 2.3
No. Lipinski's rules broken 0
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Canonical SMILES Fc1cnc(nc1)C(Nc1ncc(c(n1)Nc1[nH]nc(c1)C)Cl)C
Isomeric SMILES Fc1cnc(nc1)[C@@H](Nc1ncc(c(n1)Nc1[nH]nc(c1)C)Cl)C
InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
1. Gozgit JM, Bebernitz G, Patil P, Ye M, Parmentier J, Wu J, Su N, Wang T, Ioannidis S, Davies A et al.. (2008)
Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.
J Biol Chem, 283 (47): 32334-43. [PMID:18775810]
2. Ioannidis S, Lamb ML, Wang T, Almeida L, Block MH, Davies AM, Peng B, Su M, Zhang HJ, Hoffmann E et al.. (2011)
Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.
J Med Chem, 54 (1): 262-76. [PMID:21138246]