GtoPdb Ligand ID: 8530

Comment: CXCL12-γ is produced by alternative splicing of the CXCL12 gene and it is almost twice as large as CXCL12α and CXCL12β. It is a low affinity CXCR4 agonist and has limited signal transduction capacity. Expression of this γ isoform is mainly restricted to regions of adult brain and heart in humans and rats. In the mouse heart, CXCL12-γ localises to the nucleus via canonical nuclear localization signals and to the nucleolus via a specific nucleolar localization signal (NoLS) in its unique C-terminal region [3]. This suggests an intracellular signalling function for this isoform, which would make it unique amongst all of the known chemokines.
Species: Human
1. Rueda P, Balabanian K, Lagane B, Staropoli I, Chow K, Levoye A, Laguri C, Sadir R, Delaunay T, Izquierdo E et al.. (2008)
The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins.
PLoS ONE, 3 (7): e2543. [PMID:18648536]
2. Timotijević G, Petković F, Blaževski J, Momčilović M, Mostarica Stojković M, Miljković D. (2013)
CXCL12-γ expression is inhibited in neuroinflammation.
Brain Res., 1519: 120-6. [PMID:23651977]
3. Torres R, Ramirez JC. (2009)
A chemokine targets the nucleus: Cxcl12-gamma isoform localizes to the nucleolus in adult mouse heart.
PLoS ONE, 4 (10): e7570. [PMID:19859557]
4. Yu L, Cecil J, Peng SB, Schrementi J, Kovacevic S, Paul D, Su EW, Wang J. (2006)
Identification and expression of novel isoforms of human stromal cell-derived factor 1.
Gene, 374: 174-9. [PMID:16626895]