Classification ![]() |
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Compound class | Endogenous peptide in human, mouse or rat |
Ligand families/groups | Chemokines |
Synonyms ![]() |
SDF-1β | stromal cell-derived factor-1 (SDF-1) | stromal cell-derived factor-1β |
Comments |
CXCL12-1α and β were the first isoforms of this chemokine identified. Both proteins contain a signal peptide sequence that medaites their secretion via the canonical intracellular secretory pathway. CXCL12 participates in a variety of processes central to homeostasis and physiology, exerting its biological effects by binding to the chemokine receptors CXCR4 and CXCR7. |
Gene/Precursor ![]() |
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Database Links ![]() |
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Ensembl Gene | ENSG00000107562 (Hs) |
GtoPdb PubChem SID | 135651882 |
Human Protein Atlas | ENSG00000107562 (Hs) |
OMIM | 600835 (Hs) |
RefSeq Protein | NP_000600 (Hs) |
UniProtKB | P48061 (Hs) |
Wikipedia | SDF-1_(biology) (Hs) |