- Guide to PHARMACOLOGY
nimesulide is an approved drug
Compound class: Synthetic organic
Comment: Nimesulide is a non-steroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Ottanà R, Carotti S, Maccari R, Landini I, Chiricosta G, Caciagli B, Vigorita MG, Mini E. (2005)
In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I.
Bioorg Med Chem Lett, 15 (17): 3930-3. [PMID:15993594]
2. Pochini L, Seidita A, Sensi C, Scalise M, Eberini I, Indiveri C. (2014)
Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter. Mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling.
Biochem Pharmacol, 89 (3): 422-30. [PMID:24704252]