ChEMBL ligand: CHEMBL56367 (Aulin, Nimesulide, NSC-758412, R 805, R-805)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] Cyclooxygenase-2 in Sheep [ChEMBL: CHEMBL4102] [UniProtKB: P79208] There should be some charts here, you may need to enable JavaScript!
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] There should be some charts here, you may need to enable JavaScript!
Dipeptidyl peptidase 3 in Bos mutus [ChEMBL: CHEMBL4105778] [UniProtKB: L8I2E6] There should be some charts here, you may need to enable JavaScript!
DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] There should be some charts here, you may need to enable JavaScript!
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] There should be some charts here, you may need to enable JavaScript!
MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] There should be some charts here, you may need to enable JavaScript!
myeloperoxidase/Myeloperoxidase in Human [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] There should be some charts here, you may need to enable JavaScript!
B0AT1 in Rat [GtoPdb: 939] [UniProtKB: Q2A865] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibitory activity was evaluated against human Prostaglandin G/H synthase 1 was determined	B	4.23	pIC50	59000	nM	IC50	Bioorg Med Chem Lett (1998) 8: 529-534 [PMID:9871612]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 production	B	4.3	pIC50	50000	nM	IC50	J Med Chem (1997) 40: 980-989 [PMID:9083488]
ChEMBL	Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assay	B	4.49	pIC50	32200	nM	IC50	J Med Chem (2011) 54: 3650-3660 [PMID:21542630]
ChEMBL	The inhibitory activity against Prostaglandin G/H synthase 1 measured as TXB2 production after blood coagulation using human Whole blood assay	B	4.66	pIC50	22000	nM	IC50	J Med Chem (2002) 45: 5182-5185 [PMID:12408728]
ChEMBL	In vitro inhibition activity against cyclooxygenase 1 with the compound dissolved in DMSO	B	4.76	pIC50	17400	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3930-3933 [PMID:15993594]
GtoPdb	-	-	4.76	pIC50	17400	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3930-3 [PMID:15993594]
ChEMBL	Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassay	B	4.96	pIC50	10900	nM	IC50	Bioorg Med Chem (2009) 17: 1125-1131 [PMID:19135376]
ChEMBL	Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassay	B	5.42	pIC50	3760	nM	IC50	J Med Chem (2009) 52: 5864-5871 [PMID:19791801]
ChEMBL	Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 production	B	5.42	pIC50	3760	nM	IC50	J Med Chem (2004) 47: 6749-6759 [PMID:15615524]
ChEMBL	Inhibition of COX1	B	5.42	pIC50	3760	nM	IC50	J Med Chem (2011) 54: 2529-2591 [PMID:21413808]
ChEMBL	Inhibition of COX-1 in human whole blood assessed as thromboxane B2 level in serum after 5 mins by enzyme immunoassay	B	5.42	pIC50	3760	nM	IC50	Eur J Med Chem (2014) 74: 12-22 [PMID:24440378]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)	B	5.91	pIC50	1226	nM	IC50	DrugMatrix in vitro pharmacology data
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric method	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2015) 23: 6807-6814 [PMID:26455657]
ChEMBL	Inhibition of ovine COX1 assessed as PGF2alpha level by EIA	B	5.21	pIC50	6200	nM	IC50	Bioorg Med Chem (2011) 19: 2074-2083 [PMID:21349729]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of human COX2 expressed in baculovirus infected sf21 cells assessed as reduction in formation of oxidized TMPD using arachidonic acid as substrate preincubated for 3 to 5 mins followed by arachidonic acid addition measured for 25 secs by spectrophotometric assay	B	4.64	pIC50	23140	nM	IC50	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 production	B	5.03	pIC50	9400	nM	IC50	J Med Chem (1997) 40: 980-989 [PMID:9083488]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISA	B	5.06	pIC50	8700	nM	IC50	J Med Chem (2011) 54: 3650-3660 [PMID:21542630]
ChEMBL	Inhibition of COX2 in LPS-stimulated human whole blood assessed as TXB2 production by enzyme immunoassay	B	5.46	pIC50	3500	nM	IC50	Bioorg Med Chem (2009) 17: 1125-1131 [PMID:19135376]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate reader	B	5.77	pIC50	1684	nM	IC50	Eur J Med Chem (2021) 209: 112918-112918 [PMID:33071054]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)	B	5.84	pIC50	1436	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	The inhibitory activity against cyclooxygenase Prostaglandin G/H synthase 2 (COX-2) measured as PGE-2 production after blood coagulation using human Whole blood assay	B	5.89	pIC50	1300	nM	IC50	J Med Chem (2002) 45: 5182-5185 [PMID:12408728]
ChEMBL	Inhibition of COX-2 in human whole blood assessed as PGE2 level in plasma after 5 mins by enzyme immunoassay	B	6.15	pIC50	700	nM	IC50	Eur J Med Chem (2014) 74: 12-22 [PMID:24440378]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of LPS-stimulated PGE2 production	B	6.15	pIC50	700	nM	IC50	J Med Chem (2004) 47: 6749-6759 [PMID:15615524]
ChEMBL	Inhibition of COX2 in LPS-stimulated human whole blood assessed as PGE2 production by enzyme immunoassay	B	6.15	pIC50	700	nM	IC50	J Med Chem (2009) 52: 5864-5871 [PMID:19791801]
ChEMBL	Inhibition of COX2	B	6.15	pIC50	700	nM	IC50	J Med Chem (2011) 54: 2529-2591 [PMID:21413808]
GtoPdb	-	-	6.22	pIC50	600	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3930-3 [PMID:15993594]
ChEMBL	In vitro inhibition activity against cyclooxygenase 2 with the compound dissolved in DMSO	B	6.22	pIC50	600	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3930-3933 [PMID:15993594]
ChEMBL	Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assay	B	7.64	pIC50	23	nM	IC50	J Med Chem (2011) 54: 3650-3660 [PMID:21542630]
ChEMBL	Inhibitory activity was evaluated against human Prostaglandin G/H synthase 2 was determined	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (1998) 8: 529-534 [PMID:9871612]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL	Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric method	B	5.72	pIC50	1920	nM	IC50	Bioorg Med Chem (2015) 23: 6807-6814 [PMID:26455657]
ChEMBL	Inhibition of ovine COX2 assessed as PGF2alpha level by EIA	B	6.4	pIC50	400	nM	IC50	Bioorg Med Chem (2011) 19: 2074-2083 [PMID:21349729]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Inhibition of aromatase in SK-BR-3 cells by tritiated water release assay	B	4.57	pIC50	27000	nM	IC50	J Med Chem (2007) 50: 1635-1644 [PMID:17315855]
Dipeptidyl peptidase 3 in Bos mutus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105778] [UniProtKB: L8I2E6]
ChEMBL	Mixed type inhibition of Capra hircus (goat) brain DPP-3 using Arg-Arg-4mbetaNA as substrate assessed as liberation of 4mbetaNA from substrate preincubated for 10 min by Cornish-Bowden plot analysis	B	4.15	pKi	70000	nM	Ki	Med Chem Res (2011) 20: 1294-1297
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL	DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)	B	4.93	pKi	11826	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)	B	4.83	pIC50	14884	nM	IC50	DrugMatrix in vitro pharmacology data
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
ChEMBL	Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISA	B	4	pIC50	>100000	nM	IC50	J Med Chem (2011) 54: 3650-3660 [PMID:21542630]
ChEMBL	Inhibition of LTA4 hydrolase in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 0.5 hrs by ELISA	B	4	pIC50	>100000	nM	IC50	J Med Chem (2011) 54: 3650-3660 [PMID:21542630]
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL	DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2)	B	4.63	pIC50	23345	nM	IC50	DrugMatrix in vitro pharmacology data
myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164]
ChEMBL	Inhibition of recombinant human myeloperoxidase	B	5.68	pIC50	2100	nM	IC50	J Med Chem (2012) 55: 7208-7218 [PMID:22793255]
B0AT1 in Rat [GtoPdb: 939] [UniProtKB: Q2A865]
GtoPdb	-	-	4.64	pIC50	23000	nM	IC50	Biochem Pharmacol (2014) 89: 422-30 [PMID:24704252]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]