nimesulide   Click here for help

GtoPdb Ligand ID: 7401

Synonyms: R-805
Approved drug PDB Ligand Immunopharmacology Ligand
nimesulide is an approved drug
Compound class: Synthetic organic
Comment: Nimesulide is a non-steroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 106.92
Molecular weight 308.05
XLogP 2.63
No. Lipinski's rules broken 0
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Canonical SMILES [O-][N+](=O)c1ccc(c(c1)Oc1ccccc1)NS(=O)(=O)C
Isomeric SMILES [O-][N+](=O)c1ccc(c(c1)Oc1ccccc1)NS(=O)(=O)C
InChI InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
No information available.
Summary of Clinical Use Click here for help
Approved to treat acute pain, in patients suffering from osteoarthritis or primary dysmenorrhoea for example. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
As with other NSAIDs, this drug reduces prostaglandin synthesis by reducing cyclooxegenase (COX) activity.