IL-1 receptor antagonist   Click here for help

GtoPdb Ligand ID: 5878

Synonyms: IL-1ra | interleukin-1 receptor antagonist protein | IRAP
Immunopharmacology Ligand
Comment: A recombinant, non-glycosylated version of this protein is marketed as rheumatoid arthritis drug anakinra.
Species: Human
1. Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, TedgĂ„rd U, Cowen EW, Pham TH et al.. (2009)
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist.
N Engl J Med, 360 (23): 2426-37. [PMID:19494218]
2. Reddy S, Jia S, Geoffrey R, Lorier R, Suchi M, Broeckel U, Hessner MJ, Verbsky J. (2009)
An autoinflammatory disease due to homozygous deletion of the IL1RN locus.
N Engl J Med, 360 (23): 2438-44. [PMID:19494219]