IL-1 receptor antagonist   Click here for help

GtoPdb Ligand ID: 5878

Synonyms: IL-1ra | interleukin-1 receptor antagonist protein | IRAP
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: A recombinant, non-glycosylated version of this protein is marketed as rheumatoid arthritis drug anakinra.
Species: Human
Natural/Endogenous Targets
Target
Interleukin-1 receptor, type I
Interleukin-2 receptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
dipeptidyl peptidase 9 3
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-1 receptor, type I Ligand is endogenous in the given species Hs Antagonist Antagonist - - -
⤷
Interleukin-2 receptor Ligand is endogenous in the given species Hs Antagonist Antagonist - - -
⤷
Targets where the ligand is described in the comment field
Target Comment
Interleukin-1 receptor, type II Decoy receptor that binds IL-1α (IL1A, P01583), IL-1β (IL1B, P01584) and IL-1 receptor antagonist (IL1RN, P18510).