CD40 ligand

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Ligands
CD40 ligand (Human)

GtoPdb Ligand ID: 5077

Synonyms: CD40 ligand, membrane form

Compound class: Endogenous peptide in human, mouse or rat

Comment: The CD40 ligand precursor is also cleaved into a soluble form of the ligand

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

References
1. Karnell JL, Albulescu M, Drabic S, Wang L, Moate R, Baca M, Oganesyan V, Gunsior M, Thisted T, Yan L et al.. (2019) A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity. Sci Transl Med, 11 (489). [PMID:31019027]
2. Shock A, Burkly L, Wakefield I, Peters C, Garber E, Ferrant J, Taylor FR, Su L, Hsu YM, Hutto D et al.. (2015) CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study. Arthritis Res Ther, 17: 234. [PMID:26335795]

References

1. Karnell JL, Albulescu M, Drabic S, Wang L, Moate R, Baca M, Oganesyan V, Gunsior M, Thisted T, Yan L et al.. (2019)
A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.
Sci Transl Med, 11 (489). [PMID:31019027]

2. Shock A, Burkly L, Wakefield I, Peters C, Garber E, Ferrant J, Taylor FR, Su L, Hsu YM, Hutto D et al.. (2015)
CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study.
Arthritis Res Ther, 17: 234. [PMID:26335795]