CD40 ligand   Click here for help

GtoPdb Ligand ID: 5077

Synonyms: CD40 ligand, membrane form
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: The CD40 ligand precursor is also cleaved into a soluble form of the ligand
Species: Human
Natural/Endogenous Targets
Target
CD40
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD40 Ligand is endogenous in the given species Hs None - - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
dapirolizumab pegol Peptide Hs Antibody Binding 11.1 pKd - 2
⤷ pKd 11.1 (Kd 7.9x10-12 M) [2]
Description: Binding affinity for hCD40L in a BIAcore affinity assay.
dapirolizumab pegol Peptide Hs Antibody Binding 9.3 pIC50 - 2
⤷ pIC50 9.3 (IC50 4.9x10-10 M) [2]
Description: Measuring inhibition of CD40L binding to CD40.
dazodalibep Peptide Hs Fusion protein Binding 8.9 pIC50 - 1
⤷ pIC50 8.9 (IC50 1.4x10-9 M) [1]
Description: Measuring inhibition of CD40/CD40L interactions by enzyme-linked immunosorbent assay (ELISA)