sulfadiazine is an approved drug (FDA (1941), UK (2008))
Compound class:
Synthetic organic
Comment: Sulfadiazine is a sulfonamide with broad-spectrum antimicrobial activity [4]. It is used in the treatment of toxoplasmosis, an infection with the protozoan parasite Toxoplasma gondi that can cause serious complications during pregnancy and in patients with weakened immune systems. Dermatological formulations containing silver sulfadiazine (PubChem CID 441244) are used to prevent and treat wound infections.
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References |
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Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase. Nat Struct Biol, 4 (6): 490-7. [PMID:9187658] |
2. Bermingham A, Derrick JP. (2002)
The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays, 24 (7): 637-48. [PMID:12111724] |
3. Ovung A, Bhattacharyya J. (2021)
Sulfonamide drugs: structure, antibacterial property, toxicity, and biophysical interactions. Biophys Rev, 13 (2): 259-272. [PMID:33936318] |
4. Petersdorf RG. (1984)
Landmark perspective: Sulfadiazine. JAMA, 251 (11): 1475-6. [PMID:6366264] |