FGF-21

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Ligands
FGF-21 (Human)

GtoPdb Ligand ID: 11721

Synonyms: fibroblast growth factor 21

Compound class: Endogenous peptide in human, mouse or rat

Comment: FGF21 is a mitogen that is involved in the migration and differentiation of cells that are of mesodermal or neuroectodermal origin, and in metabolic regulation [2]. Klotho beta (KLB) appears to be required for FGF21's metabolic activity [3]. The peptide sequence provided here includes the signal peptide (MDSDETGFEHSGLWVSVLAGLLLGACQA).

Species: Human

References
1. Chen X, Tong G, Fan J, Shen Y, Wang N, Gong W, Hu Z, Zhu K, Li X, Jin L et al.. (2022) FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1-dependent autophagy. Br J Pharmacol, 179 (5): 1102-1121. [PMID:34608629]
2. Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA et al.. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest, 115 (6): 1627-35. [PMID:15902306]
3. Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-O M. (2007) Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem, 282 (37): 26687-26695. [PMID:17623664]

References

1. Chen X, Tong G, Fan J, Shen Y, Wang N, Gong W, Hu Z, Zhu K, Li X, Jin L et al.. (2022)
FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1-dependent autophagy.
Br J Pharmacol, 179 (5): 1102-1121. [PMID:34608629]

2. Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA et al.. (2005)
FGF-21 as a novel metabolic regulator.
J Clin Invest, 115 (6): 1627-35. [PMID:15902306]

3. Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-O M. (2007)
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
J Biol Chem, 282 (37): 26687-26695. [PMID:17623664]