artefenomel

Ligand id: 9971

Name: artefenomel

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 49.39
Molecular weight 469.28
XLogP 5.34
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Guide to Malaria Pharmacology Comments
Artefenomel is an antimalarial drug candidate, under clinical development as a single-dose oral cure for uncomplicated P. falciparum malaria. Artefenomel has rapid activity against the asexual blood stage of P. falciparum, demonstrates transmission-blocking activity and provides a longer terminal half-life of elimination when compared to clinically available endoperoxides [1-2,4].

Potential Target/Mechanism Of Action: As the precise mechanism of action of artefenomel is not yet known, we do not have a molecular target for this compound.
Target Candidate Profiles
Profile Intended Use Target Stage Comment References
TCP-1 reduce parasite burden asexual blood stages
TCP-5 transmission reduction gametocytes