Synonyms: OZ439
Compound class:
Synthetic organic
Comment: Artefenomel is a synthetic ozonide (synthetic peroxide), a class of compound that retains the endoperoxide bridge of the artemisinin class of antimalarials but also contains the sterically bulky amantadine ring, which increases blood plasma stability [6].
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. |
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Guide to Malaria Pharmacology Comments |
Artefenomel is an antimalarial drug candidate, under clinical development as a single-dose oral cure for uncomplicated P. falciparum malaria. Artefenomel has rapid activity against the asexual blood stage of P. falciparum, demonstrates transmission-blocking activity and provides a longer terminal half-life of elimination when compared to clinically available endoperoxides [1-2,5]. Potential Target/Mechanism Of Action: As the precise mechanism of action of artefenomel is not yet known, we do not have a molecular target for this compound. Further information about possible mechanistic insights is provided under the Clinical data tab. |
Target Candidate Profiles | ||||
Profile | Intended Use | Target Stage | Comment | References |
TCP-1 | reduce parasite burden | asexual blood stages | ||
TCP-5 | transmission reduction | gametocytes |