- Guide to PHARMACOLOGY
Compound class: Synthetic organic
Comment: Artefenomel is a synthetic ozonide (synthetic peroxide), a class of compound that retains the endoperoxide bridge of the artemisinin class of antimalarials but also contains the sterically bulky amantadine ring, which increases blood plasma stability .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
|Guide to Malaria Pharmacology Comments|
|Artefenomel is an antimalarial drug candidate, under clinical development as a single-dose oral cure for uncomplicated P. falciparum malaria. Artefenomel has rapid activity against the asexual blood stage of P. falciparum, demonstrates transmission-blocking activity and provides a longer terminal half-life of elimination when compared to clinically available endoperoxides [1-2,5].
Potential Target/Mechanism Of Action: As the precise mechanism of action of artefenomel is not yet known, we do not have a molecular target for this compound. Further information about possible mechanistic insights is provided under the Clinical data tab.
|Target Candidate Profiles|
|Profile||Intended Use||Target Stage||Comment||References|
|TCP-1||reduce parasite burden||asexual blood stages|