proguanil   

GtoPdb Ligand ID: 9676

Synonyms: Bigumal® | chloroguanide | Paludrine®
proguanil is an approved drug (FDA (2000) in combination with atovaquone)
Compound class: Synthetic organic
Comment: Proguanil is a biguanide derivative that, once administered, is converted to the active metabolite cycloguanil. It is an antimalarial drug, used in combination with atovaquone or with chloroquine.
The marketed formulations contain proguanil hydrochloride (PubChem CID 9570076).
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 88.79
Molecular weight 253.11
XLogP 1.84
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CC(N=C(N=C(Nc1ccc(cc1)Cl)N)N)C
Isomeric SMILES CC(N=C(/N=C(/Nc1ccc(cc1)Cl)\N)N)C
InChI InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17)
InChI Key SSOLNOMRVKKSON-UHFFFAOYSA-N
proguanil has been tagged as relevant to malaria pharmacology and is awaiting detailed curation for the Guide to MALARIA PHARMACOLOGY.