- Guide to PHARMACOLOGY
Molecular properties generated using the CDK
|No information available.|
|Summary of Clinical Use|
|Proguanil is used in combination with atovaquone in both the treatment of uncomplicated malaria caused by P. falciparum and in malaria prophylaxis .
Proguanil is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
|Mechanism Of Action and Pharmacodynamic Effects|
|Cycloguanil, the active metabolite of proguanil, is an inhibitor of Plasmodium dihydrofolate reductase (DHFR). Proguanil has a different mechanism of action when used in combination with atovaquone, with the prodrug having synergistic activity, leading to enhanced collapse of the mitochondrial membrane potential .|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)