Summary of Clinical Use

Proguanil is used in combination with atovaquone in both the treatment of uncomplicated malaria caused by P. falciparum and in malaria prophylaxis [1]. Proguanil is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).

Mechanism Of Action and Pharmacodynamic Effects

Cycloguanil, the active metabolite of proguanil, is an inhibitor of Plasmodium dihydrofolate reductase (DHFR). Proguanil has a different mechanism of action when used in combination with atovaquone, with the prodrug having synergistic activity, leading to enhanced collapse of the mitochondrial membrane potential [2].

External links

For extended ADME data see the following: Electronic Medicines Compendium (eMC)