- Guide to PHARMACOLOGY
Synonyms: ATB 346 | ATB-346 | ATB-346, (S)- | ATB346
Compound class: Synthetic organic
Comment: Otenaproxesul (ATB-346) is a novel, orally administered, gastrointestinal-sparing hydrogen sulfide (H2S)-releasing analgesic and anti-inflammatory drug in clinical trials for osteoarthritis . Structurally it comprises an H2S-releasing moiety covalently linked to a NSAID (naproxen). H2S-releasing NSAIDs are in development for their potential analgesic, anti-inflammatory, cytoprotective and chemopreventative properties [2-3,5-6,9-10].
|ATB-346 is an H2S-releasing NSAID. The liberation of H2S has the potential to reduce the gastrointestinal damage caused by long-term use of traditional NSAIDs, and may also enhance the anti-cancer effects of the NSAID drug .|
||ATB-346 is a clinical trial candidate for OA.|