- Guide to PHARMACOLOGY
Synonyms: ATB 346 | ATB-346 | ATB-346, (S)- | ATB346
Compound class: Synthetic organic
Comment: Otenaproxesul (ATB-346) is a novel, orally administered, gastrointestinal-sparing hydrogen sulfide (H2S)-releasing analgesic and anti-inflammatory drug in clinical trials for osteoarthritis . Structurally it comprises an H2S-releasing moiety covalently linked to a NSAID (naproxen). H2S-releasing NSAIDs are in development for their potential analgesic, anti-inflammatory, cytoprotective and chemopreventative properties [2-3,5-6,9-10].
|ATB-346 is a potent inhibitor of cyclooxygenase (COX) isozymes. ATB-346 mechanism of action is mediated in part by the release of H2S, hypothesized to be via desulfuration of its 4-hydroxy thiobenzamide moiety. The GI-sparing nature of this drug is evidenced by exposure not causing significant GI injury in rodents, dogs and humans at high doses, or in animals with impaired mucosal defense [1,4,7-8].|