otenaproxesul   Click here for help

GtoPdb Ligand ID: 9534

Synonyms: ATB 346 | ATB-346 | ATB-346, (S)- | ATB346
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Otenaproxesul (ATB-346) is a novel, orally administered, gastrointestinal-sparing hydrogen sulfide (H2S)-releasing analgesic and anti-inflammatory drug in clinical trials for osteoarthritis [8]. Structurally it comprises an H2S-releasing moiety covalently linked to a NSAID (naproxen). H2S-releasing NSAIDs are in development for their potential analgesic, anti-inflammatory, cytoprotective and chemopreventative properties [2-3,5-6,9-10].
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 93.64
Molecular weight 365.11
XLogP 4.19
No. Lipinski's rules broken 0
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Canonical SMILES COc1ccc2c(c1)ccc(c2)C(C(=O)Oc1ccc(cc1)C(=S)N)C
Isomeric SMILES COc1ccc2c(c1)ccc(c2)[C@@H](C(=O)Oc1ccc(cc1)C(=S)N)C
InChI InChI=1S/C21H19NO3S/c1-13(21(23)25-18-8-5-14(6-9-18)20(22)26)15-3-4-17-12-19(24-2)10-7-16(17)11-15/h3-13H,1-2H3,(H2,22,26)/t13-/m0/s1
Bioactivity Comments
ATB-346 is a potent inhibitor of cyclooxygenase (COX) isozymes. ATB-346 mechanism of action is mediated in part by the release of H2S, hypothesized to be via desulfuration of its 4-hydroxy thiobenzamide moiety. The GI-sparing nature of this drug is evidenced by exposure not causing significant GI injury in rodents, dogs and humans at high doses, or in animals with impaired mucosal defense [1,4,7-8].