- Guide to PHARMACOLOGY
Synonyms: 7162 RP | IL-6001 | Surmontil®
trimipramine is an approved drug (FDA (1979))
Compound class: Synthetic organic
Comment: Trimipramine is a tricyclic antidepressant (TCA) with antidepressant, anxiolytic, antipsychotic and sedative effects. Trimipramine is a racemic compound of two enantiomers; (S)-trimipramine and (R)-trimipramine. We show the non-stereo structure to represent the mixture.
Marketed formulations may contain trimipramine maleate (PubChem CID 5282318).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: trimipramine
|No information available.|
|Summary of Clinical Use|
|Used to treat major depressive disorder.|
|Mechanism Of Action and Pharmacodynamic Effects|
|The drug's main effects are antagonism of the receptors for the monoamine neurotransmitters dopamine, serotonin, epinephrine/norepinephrine and acetylcholine receptors. Trimipramine is a weak inhibitor of the norepinephrine, serotonin, and dopamine transporters (NET, SLC6A2; SET, SLC6A4; and DAT, SCL6A3 respectively). See the DrugBank link for further details.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)