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ChEMBL ligand: CHEMBL644 (7162 RP, 7162-RP, IL 6001, IL-6001, Surmontil, Trimeproprimine, Trimipramine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 4.56 | pIC50 | 27700 | nM | IC50 | J. Med. Chem. (2008) 51: 5932-5942 [PMID:18788725] |
NET in Human [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
GtoPdb | - | - | 5.61 | pKi | 2450 | nM | Ki | Eur J Pharmacol (1997) 340: 249-58 [PMID:9537821] |
DAT in Human [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
GtoPdb | - | - | 5.42 | pKi | 3780 | nM | Ki | Eur J Pharmacol (1997) 340: 249-58 [PMID:9537821] |
SERT in Human [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
GtoPdb | - | - | 6.83 | pKi | 149 | nM | Ki | Eur J Pharmacol (1997) 340: 249-58 [PMID:9537821] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]