ROMe   Click here for help

GtoPdb Ligand ID: 6625

Synonyms: (R)-FTY720 methyl ether | (R)-FTY720-OMe
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: ROMe is a synthetic sphingosine analogue.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 55.48
Molecular weight 321.27
XLogP 5.11
No. Lipinski's rules broken 2
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Canonical SMILES CCCCCCCCc1ccc(cc1)CCC(COC)(CO)N
Isomeric SMILES CCCCCCCCc1ccc(cc1)CC[C@](COC)(CO)N
InChI InChI=1S/C20H35NO2/c1-3-4-5-6-7-8-9-18-10-12-19(13-11-18)14-15-20(21,16-22)17-23-2/h10-13,22H,3-9,14-17,21H2,1-2H3/t20-/m1/s1
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Mechanism Of Action and Pharmacodynamic Effects Click here for help
Sphingosine kinase 2 (SK2) phosphorylates sphingosine to generate sphingosine 1-phosphate (S1P) and also phopshorylates the synthetic sphingosine analogue FTY720 [4]. FTY720 phosphate acts as an immunosuppressant by inhibiting the normal activation of S1P receptors by S1P which would normally stimulate T-lymphocyte egress from the lymph nodes [3]. ROMe is another synthetic sphingosine analogue with potential immunosuppressant/antineoplastic action [2].