ROMe [Ligand Id: 6625] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL2158686 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| sphingosine kinase 1/Sphingosine kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4394] [GtoPdb: 2204] [UniProtKB: Q9NYA1] | ||||||||
| ChEMBL | Inhibition of human SphK1 using sphingosine as substrate after 15 to 20 mins in presence of [gamma-32P]ATP by Cerenkov counting method | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2017) 25: 3046-3052 [PMID:28408190] |
| sphingosine kinase 2/Sphingosine kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3023] [GtoPdb: 2205] [UniProtKB: Q9NRA0] | ||||||||
| ChEMBL | Inhibition of SphK2 (unknown origin) | B | 4.57 | pKi | 27000 | nM | Ki | J Med Chem (2014) 57: 5509-5524 [PMID:24471412] |
| GtoPdb | - | - | 4.78 | pKi | 16500 | nM | Ki | Cell Signal (2011) 23: 1590-5 [PMID:21620961] |
| ChEMBL | Inhibition of SphK2 using sphingosine as substrate and [32gammaP]ATP after 15 to 20 mins by Cerenkov counting analysis | B | 4.78 | pKi | 16500 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 6817-6820 [PMID:22321213] |
| ChEMBL | Inhibition of SK2 (unknown origin) | B | 4.78 | pKi | 16500 | nM | Ki | Medchemcomm (2013) 4: 1394-1399 [PMID:24396570] |
| ChEMBL | Inhibition of SphK2 (unknown origin) | B | 4.78 | pKi | 16500 | nM | Ki | ACS Med Chem Lett (2016) 7: 229-234 [PMID:26985306] |
| ChEMBL | Inhibition of recombinant SphK2 (unknown origin) using sphingosine as substrate incubated for 15 to 20 mins by [gamma32P]-ATP based assay | B | 4.78 | pKi | 16500 | nM | Ki | Eur J Med Chem (2020) 206: 112713-112713 [PMID:32919113] |
| ChEMBL | Inhibition of human SphK2 using sphingosine as substrate after 15 to 20 mins in presence of [gamma-32P]ATP by Cerenkov counting method | B | 4.57 | pIC50 | 27000 | nM | IC50 | Bioorg Med Chem (2017) 25: 3046-3052 [PMID:28408190] |
| GtoPdb | - | - | 4.57 | pIC50 | 27000 | nM | IC50 | Cell Signal (2011) 23: 1590-5 [PMID:21620961] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
