ROMe [Ligand Id: 6625] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2158686 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| sphingosine kinase 1/Sphingosine kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4394] [GtoPdb: 2204] [UniProtKB: Q9NYA1] | ||||||||
| ChEMBL | Inhibition of human SphK1 using sphingosine as substrate after 15 to 20 mins in presence of [gamma-32P]ATP by Cerenkov counting method | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2017) 25: 3046-3052 [PMID:28408190] |
| sphingosine kinase 2/Sphingosine kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3023] [GtoPdb: 2205] [UniProtKB: Q9NRA0] | ||||||||
| ChEMBL | Inhibition of SphK2 (unknown origin) | B | 4.57 | pKi | 27000 | nM | Ki | J Med Chem (2014) 57: 5509-5524 [PMID:24471412] |
| GtoPdb | - | - | 4.78 | pKi | 16500 | nM | Ki | Cell Signal (2011) 23: 1590-5 [PMID:21620961] |
| ChEMBL | Inhibition of SphK2 using sphingosine as substrate and [32gammaP]ATP after 15 to 20 mins by Cerenkov counting analysis | B | 4.78 | pKi | 16500 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 6817-6820 [PMID:22321213] |
| ChEMBL | Inhibition of SK2 (unknown origin) | B | 4.78 | pKi | 16500 | nM | Ki | Medchemcomm (2013) 4: 1394-1399 [PMID:24396570] |
| ChEMBL | Inhibition of SphK2 (unknown origin) | B | 4.78 | pKi | 16500 | nM | Ki | ACS Med Chem Lett (2016) 7: 229-234 [PMID:26985306] |
| ChEMBL | Inhibition of recombinant SphK2 (unknown origin) using sphingosine as substrate incubated for 15 to 20 mins by [gamma32P]-ATP based assay | B | 4.78 | pKi | 16500 | nM | Ki | Eur J Med Chem (2020) 206: 112713-112713 [PMID:32919113] |
| ChEMBL | Inhibition of human SphK2 using sphingosine as substrate after 15 to 20 mins in presence of [gamma-32P]ATP by Cerenkov counting method | B | 4.57 | pIC50 | 27000 | nM | IC50 | Bioorg Med Chem (2017) 25: 3046-3052 [PMID:28408190] |
| GtoPdb | - | - | 4.57 | pIC50 | 27000 | nM | IC50 | Cell Signal (2011) 23: 1590-5 [PMID:21620961] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
