- Guide to PHARMACOLOGY
Synonyms: N-tert-Butyl isoquine
Compound class: Synthetic organic
Comment: GSK369796 is a 4-aminoquinoline antimalarial compound that was synthesised using amodiaquine as the template molecule .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|A Phase 1 clinical trial (NCT00675064) to assess the safety, tolerability, and pharmacokinetics of GSK369796 has been completed. The study was stopped by the sponsor after a seizure was experienced by one subject following administration of the drug.|
|Clinical Trial ID||Title||Type||Source||Comment||References|
|NCT00675064||Single-Blind, Placebo-Controlled, Randomized Study Testing Single Ascending Doses Of GSK369796 In Healthy Subjects||Phase 1 Interventional||GlaxoSmithKline|