GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
Synonyms: N-tert-Butyl isoquine
Compound class:
Synthetic organic
Comment: GSK369796 is a 4-aminoquinoline antimalarial compound that was synthesised using amodiaquine as the template molecule [3].
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. |
|
Bioactivity Comments |
The interaction table below provides data from whole cell assays and gives the antiparasite activity of GSK369796 against a number of Plasmodium lifecycle stages. The results include evaluations of asexual blood stage activity using culture-adapted P. falciparum strains, with GSK369796 demonstrating no evidence of reduced potency against drug resistant strains. In addition, GSK369796 demonstrates oral activity equivalent to amodiaquine when tested in a P. berghei ANKA mouse model (ED90 of 4.7 mg/kg) [3]. |
Whole organism assay data | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click on species/strain names for details | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|