- Guide to PHARMACOLOGY
Synonyms: N-tert-Butyl isoquine
Compound class: Synthetic organic
Comment: GSK369796 is a 4-aminoquinoline antimalarial compound that was synthesised using amodiaquine as the template molecule .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|The interaction table below provides data from whole cell assays and gives the antiparasite activitity of GSK369796 against a number of Plasmodium lifecycle stages. The results include evaluations of asexual blood stage activity using culture-adapted P. falciparum strains, with GSK369796 demonstrating no evidence of reduced potency against drug resistant strains. In addition, GSK369796 demonstrates oral activity equivalent to amodiaquine when tested in a P. berghei ANKA mouse model (ED90 of 4.7 mg/kg) .|
|Whole organism assay data|
|Key to terms and symbols||Click on species/strain names for details||Click column headers to sort|