Ligand id: 10173

Name: sulfadoxine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 124.81
Molecular weight 310.07
XLogP 0.62
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The 1981 US FDA approval for this compound is in combination with pyrimethamine (trade name Fansidar®). Sulfadoxine is listed in the World Health Organisation's 21st Essential Medicines List (2019) as a curative treatment for uncomplicated P. falciparum malaria in combination with pyrimethamine and artesunate. This is one of the artemisinin-based combination therapies (ACTs) recommended in the WHO's Guidelines for the treatment of malaria [2].
The link to extended ADME data provided below is for the combined formulation with pyrimethamine.
External links