pipotiazine   Click here for help

GtoPdb Ligand ID: 7557

Synonyms: Piportil® | pipothiazine
Approved drug
pipotiazine is an approved drug (UK (1980))
Compound class: Synthetic organic
Comment: Pipotiazine is a phenothiazine class typical antipsychotic.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 97.77
Molecular weight 475.2
XLogP 3.78
No. Lipinski's rules broken 0
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Canonical SMILES OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C
Isomeric SMILES OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C
InChI InChI=1S/C24H33N3O3S2/c1-25(2)32(29,30)20-8-9-24-22(18-20)27(21-6-3-4-7-23(21)31-24)14-5-13-26-15-10-19(11-16-26)12-17-28/h3-4,6-9,18-19,28H,5,10-17H2,1-2H3
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
D2 receptor Primary target of this compound Hs Antagonist Antagonist 9.7 pKi - 1
pKi 9.7 (Ki 2x10-10 M) [1]