pipotiazine   Click here for help

GtoPdb Ligand ID: 7557

Synonyms: Piportil® | pipothiazine
Approved drug
pipotiazine is an approved drug (UK (1980))
Compound class: Synthetic organic
Comment: Pipotiazine is a phenothiazine class typical antipsychotic.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 97.77
Molecular weight 475.2
XLogP 3.78
No. Lipinski's rules broken 0
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Canonical SMILES OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C
Isomeric SMILES OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C
InChI InChI=1S/C24H33N3O3S2/c1-25(2)32(29,30)20-8-9-24-22(18-20)27(21-6-3-4-7-23(21)31-24)14-5-13-26-15-10-19(11-16-26)12-17-28/h3-4,6-9,18-19,28H,5,10-17H2,1-2H3
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Summary of Clinical Use Click here for help
Used to treat schizophrenia.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
This drug has multifunctional actions. It has been reported as an antagonist at dopamine D2 and D3 receptors, serotonin 5-HT2 receptors, α1-adrenoceptors, histamine H1 receptor and muscarinic acetylcholine M1-4 receptors. Drug action improves psychotic symptoms in schizophrenia patients.
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