α-CGRP   

GtoPdb Ligand ID: 681

Synonyms: α-calcitonin gene-related peptide (αCGRP, human) | calcitonin gene-related peptide 1 (CGRP)
Comment: This peptide is an isoform of calcitonin, encoded by the same gene and produced by alternative splicing. Please note that each peptide is represented by a different UniProt ID.
Species: Human
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Natural/Endogenous Targets
Target
AM1 receptor
AM2 receptor
AMY1 receptor
AMY2 receptor
AMY3 receptor
CGRP receptor
CT receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
AM1 receptor Hs Agonist Full agonist 6.0 pKd - 9
pKd 6.0 [9]
CGRP receptor Hs Agonist Full agonist 9.7 – 10.0 pKi - 1,9
pKi 9.7 – 10.0 [1,9]
AM2 receptor Hs Agonist Full agonist 6.5 – 6.8 pKi - 1,3
pKi 6.5 – 6.8 [1,3]
AMY1 receptor Hs Agonist Full agonist 8.7 – 10.8 pEC50 - 5-8,10
pEC50 8.7 – 10.8 [5-8,10]
AMY3 receptor Hs Agonist Full agonist 7.6 – 9.7 pEC50 - 5-7
pEC50 7.6 – 9.7 [5-7]
AMY2 receptor Hs Agonist Full agonist 6.2 – 9.7 pEC50 - 5-7
pEC50 6.2 – 9.7 [5-7]
CT receptor Hs Agonist Full agonist 6.2 – 8.4 pEC50 - 5-6,8,12
pEC50 6.2 – 8.4 [5-6,8,12]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
fremanezumab Hs Antibody Binding >10.3 pKd - 11
pKd >10.3 (Kd <5x10-11 M) [11]
galcanezumab Hs Antibody Binding 8.7 pKd - 2
pKd 8.7 (Kd 2.2x10-9 M) [2]
eptinezumab Hs Antibody Binding 10.0 pEC50 - 4
pEC50 10.0 (EC50 1.03x10-10 M) [4]
Description: Binding affinity for α-CGRP determined in an ELISA.
Ligand mentioned in the following text fields