amylin   Click here for help

GtoPdb Ligand ID: 687

Abbreviated name: AMY
Compound class: Endogenous peptide in human, mouse or rat
Comment: Amylin acts as an appetite suppressor. Novo Nordisk have a long-acting amylin mimetic (AM833, NNC0174-0833) in clinical trials with and without semaglutide. AM833 is intended as a treatment for obesity. In the trials it is administered subcutaneously, once-weekly. Preliminary (and as yet unpublished) results from a Phase 2 trial as monotherapy demonstrated weight loss of 10.8% at week 26, meeting the study's primary endpoint (Novo Nordisk press release 18 Jun 2020).
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
IAPP islet amyloid polypeptide Human pre-pro-IAPP DAP, IAP
Database Links Click here for help
Specialist databases
GPCRdb Ligand amylin
Other databases
CAS Registry No. 122384-88-7 (Hs)
Ensembl Gene ENSG00000121351 (Hs)
Entrez Gene 3375 (Hs)
GtoPdb PubChem SID 135651612
Human Protein Atlas ENSG00000121351 (Hs)
UniProtKB P10997 (Hs)
Wikipedia Amylin