α-CGRP   

GtoPdb Ligand ID: 681

Synonyms: α-calcitonin gene-related peptide (αCGRP, human) | calcitonin gene-related peptide 1 (CGRP)
Comment: This peptide is an isoform of calcitonin, encoded by the same gene and produced by alternative splicing. Please note that each peptide is represented by a different UniProt ID.
Species: Human
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References
1. Aiyar N, Disa J, Pullen M, Nambi P. (2001)
Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells.
Mol. Cell. Biochem., 224 (1-2): 123-33. [PMID:11693189]
2. Benschop RJ, Gehlert DR, Merchant KM, Shanafelt AB. (2007)
Treatment of migraine with anti-CGRP antibodies.
Patent number: WO2007076336 A1. Assignee: Eli Lilly Co., Benschop RJ, Gehlert DR, Merchant KM, Shanafelt AB. Priority date: 22/12/2005. Publication date: 05/07/2007.
3. Fraser NJ, Wise A, Brown J, McLatchie LM, Main MJ, Foord SM. (1999)
The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor.
Mol Pharmacol., 55: 1054-1059. [PMID:10347248]
4. Garcia-Martinez LF, Kaiser EA, Kovacevich BR, Kuburas A, Latham JA, Raddant AC, Recober A, Russo AF, Smith JTL. (2012)
Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers.
Patent number: WO2012162257A2. Assignee: Alderbio Holdings Llc, The University Of Iowa Research Foundation. Priority date: 20/05/2011. Publication date: 29/11/2012.
5. Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM. (2005)
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Mol. Pharmacol., 67 (5): 1655-65. [PMID:15692146]
6. Kuwasako K, Cao YN, Nagoshi Y, Tsuruda T, Kitamura K, Eto T. (2004)
Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins.
Mol. Pharmacol., 65 (1): 207-13. [PMID:14722252]
7. Kuwasako K, Kitamura K, Nagoshi Y, Eto T. (2003)
Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins.
Biochem. Biophys. Res. Commun., 301 (2): 460-4. [PMID:12565884]
8. Leuthauser K, Gujer R, Aldecoa A, McKinney RA, Muff R, Fischer JA, Born W. (2000)
Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition.
Biochem J., 351: 347-351. [PMID:11023820]
9. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998)
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.
Nature, 393 (6683): 333-9. [PMID:9620797]
10. Walker CS, Eftekhari S, Bower RL, Wilderman A, Insel PA, Edvinsson L, Waldvogel HJ, Jamaluddin MA, Russo AF, Hay DL. (2015)
A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.
Ann Clin Transl Neurol, 2 (6): 595-608. [PMID:26125036]
11. Zeller J, Poulsen KT, Abdiche YN, Pons J, Collier SJ, Rosenthal A. (2007)
Antagonist antibodies directed against calcitonin gene-related peptide and methods using same.
Patent number: WO2007054809. Assignee: Rinat Neuroscience Corp.. Priority date: 14/11/2005. Publication date: 18/05/2007.
12. Zimmermann U, Fluehmann B, Born W, Fischer JA, Muff R. (1997)
Coexistence of novel amylin-binding sites with calcitonin receptors in human breast carcinoma MCF-7 cells.
J. Endocrinol., 155 (3): 423-31. [PMID:9487987]