PHV   

GtoPdb Ligand ID: 2275

Synonyms: intestinal peptide PHV-42 | peptide histidine-valine
Comment: The rat sequence has been used in pharmacological studies. The human sequence differs at residues 17, 27 and 31. The mouse sequence has C-terminal isoleucine.
Species: Rat
Natural/Endogenous Targets
Target
PAC1 receptor
VPAC1 receptor
VPAC2 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
VPAC1 receptor Rn Agonist Agonist 8.5 pIC50 - 1
pIC50 8.5 (IC50 3x10-9 M) [1]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC2 receptor Rn Agonist Agonist 8.2 pIC50 - 1
pIC50 8.2 (IC50 6x10-9 M) [1]
Description: inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC2 receptor Hs Agonist Agonist 8.0 pIC50 - 1
pIC50 8.0 (IC50 1x10-8 M) [1]
Description: inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC1 receptor Hs Agonist Agonist 5.5 pIC50 - 1
pIC50 5.5 (IC50 3x10-6 M) [1]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor