- Guide to PHARMACOLOGY
Synonyms: compound 34 [PMID: 31609613] | LASW-1393
Compound class: Synthetic organic
Comment: LASW1393 is a pan-JAK inhibitor that was developed as an inhalation anti-inflammatory . It is active in vivo in a rat model of airway inflammation.
PubChem CID 71062030 represents the compound without specified stereochemistry.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Aurora A, FGFR1, Flt4, Ret, and TrkA are potential off-targets of LASW1393. These off-targets are inhibited by >75% at a compound concentration of 10 μM. LASW1393 exhibits low in vitro cytotoxicity.|
|Selectivity at enzymes|
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