LASW1393   Click here for help

GtoPdb Ligand ID: 10527

Synonyms: compound 34 [PMID: 31609613] | LASW-1393
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: LASW1393 is a pan-JAK inhibitor that was developed as an inhalation anti-inflammatory [1]. It is active in vivo in a rat model of airway inflammation.
PubChem CID 71062030 represents the compound without specified stereochemistry.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 132.25
Molecular weight 365.16
XLogP 1.34
No. Lipinski's rules broken 0
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Canonical SMILES N#CCC1CCC(CC1)n1c(=O)[nH]c2c1nc(nc2)Nc1ccc[nH]c1=O
Isomeric SMILES N#CC[C@@H]1CC[C@H](CC1)n1c(=O)[nH]c2c1nc(nc2)Nc1ccc[nH]c1=O
InChI InChI=1S/C18H19N7O2/c19-8-7-11-3-5-12(6-4-11)25-15-14(23-18(25)27)10-21-17(24-15)22-13-2-1-9-20-16(13)26/h1-2,9-12H,3-7H2,(H,20,26)(H,23,27)(H,21,22,24)/t11-,12-
Bioactivity Comments
Aurora A, FGFR1, Flt4, Ret, and TrkA are potential off-targets of LASW1393. These off-targets are inhibited by >75% at a compound concentration of 10 μM. LASW1393 exhibits low in vitro cytotoxicity.
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Janus kinase 2 Hs Inhibitor Inhibition 8.8 pIC50 - 1
pIC50 8.8 (IC50 1.5x10-9 M) [1]
Janus kinase 3 Hs Inhibitor Inhibition 8.5 pIC50 - 1
pIC50 8.5 (IC50 3.5x10-9 M) [1]
Janus kinase 1 Hs Inhibitor Inhibition 8.3 pIC50 - 1
pIC50 8.3 (IC50 5.5x10-9 M) [1]
tyrosine kinase 2 Hs Inhibitor Inhibition 6.9 pIC50 - 1
pIC50 6.9 (IC50 1.3x10-7 M) [1]