SS148 
GtoPdb Ligand ID: 13635
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Synonyms: SS-148
Compound class:
Synthetic organic
Comment: SS148 behaves as an inhibitor of coronavirus methyltransferases (MTases) nsp14 and nsp16 [1]. Broad spectrum inhibition has been reported against nsp10/nsp16 complexes from all 7 of the coronaviruses that infect humans, but it shows poor selectivity over human MTases. The CoV MTases are essential for viral RNA capping and enabling the virus to evade immune detection in humans.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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