Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1616	19p13.2	DNMT1	DNA methyltransferase 1
Mouse	-	1620	9 7.66 cM	Dnmt1	DNA methyltransferase 1
Rat	-	1622	8q13	Dnmt1	DNA methyltransferase 1

Previous and Unofficial Names

CXXC9 | MCMT | DNA (cytosine-5-)-methyltransferase 1 | DNA methyltransferase (cytosine-5) 1

Database Links
Alphafold	P26358 (Hs), P13864 (Mm), Q9Z330 (Rn)
BRENDA	2.1.1.37
ChEMBL Target	CHEMBL1993 (Hs), CHEMBL3351195 (Mm)
DrugBank Target	P26358 (Hs)
Ensembl Gene	ENSG00000130816 (Hs), ENSMUSG00000004099 (Mm), ENSRNOG00000039859 (Rn)
Entrez Gene	1786 (Hs), 13433 (Mm), 84350 (Rn)
Human Protein Atlas	ENSG00000130816 (Hs)
KEGG Enzyme	2.1.1.37
KEGG Gene	hsa:1786 (Hs), mmu:13433 (Mm), rno:84350 (Rn)
OMIM	126375 (Hs)
Orphanet	ORPHA270026 (Hs)
Pharos	P26358 (Hs)
RefSeq Nucleotide	NM_001130823 (Hs), NM_001199431 (Mm), NM_053354 (Rn)
RefSeq Protein	NP_001124295 (Hs), NP_001186360 (Mm), NP_445806 (Rn)
UniProtKB	P26358 (Hs), P13864 (Mm), Q9Z330 (Rn)
Wikipedia	DNMT1 (Hs)

Enzyme Reaction
EC Number: 2.1.1.37

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference bromo-deaza-SAH Hs Inhibition 6.0 pKi 4 ⤷ pKi 6.0 (Ki 9.5x10-7 M) [4] GSK3685032 Hs Inhibition 6.6 pIC50 2 ⤷ pIC50 6.6 (IC50 2.3x10-7 M) [2] Description: Determined using a fluorescence-coupled breaklight assay and full-length hDNMT1 SGI-1027 Hs Inhibition 6.1 pIC50 3 ⤷ pIC50 6.1 (IC50 8.5x10-7 M) [3] Description: Value derived from a nanoscale HTS assay.
Inhibitor Comments
Azacitidine and decitabine are likely to be inhibitors of DNMT1 and DNMT3A. We infer primary target designation from reports of drug action in in vitro and in vivo studies despite the paucity of pharmacological affinity data.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant; ADCADN OMIM: 604121 Orphanet: ORPHA314404
Disease:  Neuropathy, hereditary sensory, type IE; HSN1E Disease Ontology: DOID:0050548 OMIM: 614116

General Comments
Based on in vitro analysis, DNMT1 is proposed to bind the ORF8 protein of the SARS-CoV-2 virus [1], although the relevance of this interaction is unclear.