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A2B receptor

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Target id: 20

Nomenclature: A2B receptor

Family: Adenosine receptors

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 332 17p12 ADORA2B adenosine A2b receptor 63
Mouse 7 332 11 B2 Adora2b adenosine A2b receptor 52
Rat 7 332 10q23 Adora2b adenosine A2B receptor 69
Previous and Unofficial Names Click here for help
adenosine receptor A2b | A2b | A2BR
Database Links Click here for help
Specialist databases
GPCRDB aa2br_human (Hs), aa2br_mouse (Mm), aa2br_rat (Rn)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
adenosine

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
BAY 60-6583 Small molecule or natural product Click here for species-specific activity table Hs Agonist 8.0 – 8.5 pKi 22
pKi 8.0 – 8.5 (Ki 1x10-8 – 3x10-9 M) [22]
2-hexynyl-NECA Small molecule or natural product Click here for species-specific activity table Hs Full agonist 6.6 pKi 73
pKi 6.6 [73]
BAY 60-6583 Small molecule or natural product Mm Agonist 6.5 pKi 48
pKi 6.5 (Ki 3.3x10-7 M) [48]
NECA Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 5.7 – 6.9 pKi 7,11,37,50,70,73,80
pKi 5.7 – 6.9 [7,11,37,50,70,73,80]
NECA Small molecule or natural product Ligand has a PDB structure Mm Agonist 5.7 pKi 51
pKi 5.7 (Ki 1.9x10-6 M) [51]
adenosine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Rn Agonist 5.3 pKi 80
pKi 5.3 (Ki 5.1x10-6 M) [80]
CGS 21680 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn Agonist <5.0 pKi 49
pKi <5.0 (Ki >1x10-5 M) [49]
Cl-IB-MECA Small molecule or natural product Click here for species-specific activity table Hs Agonist <5.0 pKi 49
pKi <5.0 (Ki >1x10-5 M) [49]
Cl-IB-MECA Small molecule or natural product Click here for species-specific activity table Mm Agonist <5.0 pKi 49
pKi <5.0 (Ki >1x10-5 M) [49]
TCPA Small molecule or natural product Click here for species-specific activity table Hs Agonist <5.0 pKi 8
pKi <5.0 (Ki >1x10-5 M) [8]
regadenoson Small molecule or natural product Approved drug Click here for species-specific activity table Hs Agonist <5.0 pKi 36
pKi <5.0 (Ki >1x10-5 M) [36]
MRS3558 Small molecule or natural product Click here for species-specific activity table Hs Agonist <5.0 pKi 36
pKi <5.0 (Ki >1x10-5 M) [36]
adenosine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Hs Agonist 4.8 pKi 29-30,80
pKi 4.8 (Ki 1.5x10-5 M) [29-30,80]
2-chloroadenosine Small molecule or natural product Click here for species-specific activity table Hs Full agonist 4.6 – 5.0 pKi 7,13,50
pKi 4.6 – 5.0 [7,13,50]
(R)-PIA Small molecule or natural product Mm Agonist 4.7 pKi 12
pKi 4.7 (Ki 1.9x10-5 M) [12]
(S)-PIA Small molecule or natural product Click here for species-specific activity table Hs Full agonist 4.2 – 5.2 pKi 50,73
pKi 4.2 – 5.2 [50,73]
AB-NECA Small molecule or natural product Hs Full agonist 4.7 pKi 50
pKi 4.7 [50]
(R)-PIA Small molecule or natural product Click here for species-specific activity table Hs Full agonist 3.8 – 5.5 pKi 7,13,37,50,73
pKi 3.8 – 5.5 [7,13,37,50,73]
piclidenoson Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Full agonist 4.3 – 4.9 pKi 36,50
pKi 4.3 – 4.9 [36,50]
cyclopentyladenosine Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 4.5 – 4.7 pKi 36,50
pKi 4.5 – 4.7 [36,50]
CCPA Small molecule or natural product Click here for species-specific activity table Hs Full agonist 4.4 – 4.7 pKi 36,50
pKi 4.4 – 4.7 [36,50]
HEMADO Small molecule or natural product Click here for species-specific activity table Hs Agonist <4.5 pKi 46,77
pKi <4.5 (Ki >3x10-5 M) [46,77]
GS9667 Small molecule or natural product Click here for species-specific activity table Hs Agonist <4.3 pKi 25
pKi <4.3 (Ki >5x10-5 M) [25]
CGS 21680 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 3.4 – 5.0 pKi 7,36,50
pKi 3.4 – 5.0 [7,36,50]
N(6)-cyclohexyladenosine Small molecule or natural product Click here for species-specific activity table Hs Agonist 3.8 pKi 13
pKi 3.8 (Ki 1.6x10-4 M) [13]
binodenoson Small molecule or natural product Click here for species-specific activity table Hs Agonist 3.4 pKi 36
pKi 3.4 (Ki 4.3x10-4 M) [36]
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
xanthine amine congener Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 7.9 pA2 2
pA2 7.9 [2]
CGS 15943 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.8 pA2 2
pA2 7.8 [2]
[3H]MRS1754 Small molecule or natural product Ligand is labelled Ligand is radioactive Hs Antagonist 9.8 pKd 37
pKd 9.8 (Kd 1.58x10-10 M) [37]
[3H]OSIP339391 Small molecule or natural product Ligand is labelled Ligand is radioactive Hs Antagonist 9.8 pKd 70
pKd 9.8 [70]
[3H]PSB603 Small molecule or natural product Ligand is labelled Ligand is radioactive Mm Antagonist 9.5 pKd 10
pKd 9.5 [10]
PSB603 Small molecule or natural product Mm Antagonist 9.4 pKd 10
pKd 9.4 (Kd 3.51x10-10 M) [10]
[3H]PSB603 Small molecule or natural product Ligand is labelled Ligand is radioactive Hs Antagonist 9.4 pKd 10
pKd 9.4 [10]
PSB603 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 9.4 pKd 10
pKd 9.4 (Kd 4.03x10-10 M) [10]
[3H]DPCPX Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Antagonist 7.4 pKd 70
pKd 7.4 [70]
[125I]ABOPX Small molecule or natural product Ligand is labelled Ligand is radioactive Hs Antagonist 7.4 pKd 50
pKd 7.4 [50]
[3H]ZM 241385 Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Antagonist 6.5 – 7.9 pKd 27,38,70
pKd 6.5 – 7.9 [27,38,70]
PSB-0788 Small molecule or natural product Hs Antagonist 9.4 pKi 10
pKi 9.4 [10]
OSIP339391 Small molecule or natural product Hs Antagonist 9.3 pKi 70
pKi 9.3 [70]
PSB603 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 9.3 pKi 10
pKi 9.3 (Ki 5.53x10-10 M) [10]
MRS1706 Small molecule or natural product ? Antagonist 8.9 pKi 45
pKi 8.9 [45]
MRS1754 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.8 pKi 37,45
pKi 8.8 (Ki 1.58x10-9 M) [37,45]
ATL802 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.6 pKi 45
pKi 8.6 (Ki 2.36x10-9 M) [45]
MRS1754 Small molecule or natural product Mm Antagonist 8.5 pKi 4
pKi 8.5 (Ki 3.39x10-9 M) [4]
ISAM-140 Small molecule or natural product Hs Antagonist 8.5 pKi 23
pKi 8.5 (Ki 3.49x10-9 M) [23]
AS99 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.4 pKi 73
pKi 8.4 [73]
AS101 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Antagonist 8.4 pKi 73
pKi 8.4 [73]
MRE 2029F20 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.3 – 8.5 pKi 5,73
pKi 8.3 – 8.5 [5,73]
AS100 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.2 pKi 73
pKi 8.2 [73]
AS70 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.1 pKi 73
pKi 8.1 [73]
ATL802 Small molecule or natural product Click here for species-specific activity table Mm Antagonist 8.1 pKi 45
pKi 8.1 (Ki 8.58x10-9 M) [45]
CGS 15943 Small molecule or natural product Mm Antagonist 8.0 pKi 4
pKi 8.0 (Ki 9.07x10-9 M) [4]
AS96 Small molecule or natural product Hs Antagonist 8.0 pKi 73
pKi 8.0 [73]
DEPX Small molecule or natural product Hs Antagonist 7.9 pKi 50
pKi 7.9 [50]
xanthine amine congener Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 6.9 – 8.8 pKi 7,37-38,47,50,70
pKi 6.9 – 8.8 [7,37-38,47,50,70]
MRS1754 Small molecule or natural product Click here for species-specific activity table Rn Antagonist 7.8 – 7.9 pKi 28,45
pKi 7.8 – 7.9 (Ki 1.66x10-8 – 1.28x10-8 M) [28,45]
AS94 Small molecule or natural product Hs Antagonist 7.8 pKi 73
pKi 7.8 [73]
LAS38096 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.8 pKi 20,75
pKi 7.8 (Ki 1.7x10-8 M) [20,75]
AS16 Small molecule or natural product Hs Antagonist 7.7 pKi 73
pKi 7.7 [73]
AS95 Small molecule or natural product Hs Antagonist 7.7 pKi 73
pKi 7.7 [73]
CVT-6883 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.7 pKi 24
pKi 7.7 (Ki 2.2x10-8 M) [24]
AS74 Small molecule or natural product Hs Antagonist 7.6 pKi 73
pKi 7.6 [73]
ZM-241385 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 6.8 – 8.2 pKi 7,37,50,70
pKi 6.8 – 8.2 [7,37,50,70]
I-ABOPX Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.4 pKi 50
pKi 7.4 [50]
CPX Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.3 pKi 37,50
pKi 7.3 [37,50]
BW-A1433 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.3 pKi 50
pKi 7.3 [50]
XCC Small molecule or natural product Hs Antagonist 7.3 pKi 37
pKi 7.3 [37]
PSB1115 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Antagonist 7.3 pKi 33
pKi 7.3 (Ki 5.34x10-8 M) [33]
vipadenant Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Antagonist 7.2 pKi 32
pKi 7.2 (Ki 6.3x10-8 M) [32]
AZD4635 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Antagonist 7.2 pKi 9
pKi 7.2 (Ki 6.4x10-8 M) [9]
Description: Binding affinity of AZD4635 determined in a radioligand binding competition assays with membranes prepared from HEK-293-T cells stably expressing human A2BR.
DPCPX Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.9 – 7.3 pKi 44,61,70,78
pKi 6.9 – 7.3 [44,61,70,78]
DPCPX Small molecule or natural product Mm Antagonist 7.1 pKi 4
pKi 7.1 (Ki 8.62x10-8 M) [4]
CGS 15943 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.0 – 8.1 pKi 4,37-38,47,62,70
pKi 6.0 – 8.1 [4,37-38,47,62,70]
tonapofylline Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.1 pKi 42
pKi 7.1 (Ki 9x10-8 M) [42]
BAY-545 Small molecule or natural product Hs Antagonist 7.0 pKi 35
pKi 7.0 (Ki 9.7x10-8 M) [35]
PSB36 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.7 pKi 43
pKi 6.7 (Ki 1.87x10-7 M) [43]
DPCPX Small molecule or natural product Click here for species-specific activity table Rn Antagonist 6.7 – 6.7 pKi 28,44
pKi 6.7 – 6.7 (Ki 2x10-7 – 1.86x10-7 M) [28,44]
rolofylline Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.5 pKi 42
pKi 6.5 (Ki 2.96x10-7 M) [42]
LUF5981 Small molecule or natural product Click here for species-specific activity table Hs Antagonist <6.5 pKi 40
pKi <6.5 (Ki >3x10-7 M) [40]
MRS1220 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.5 pKi 70
pKi 6.5 [70]
ST-1535 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.4 pKi 54
pKi 6.4 (Ki 3.523x10-7 M) [54]
DAX Small molecule or natural product Hs Antagonist 6.4 pKi 37
pKi 6.4 [37]
3-isobutyl-8-pyrrolidinoxanthine Small molecule or natural product Hs Antagonist 6.3 pKi 27
pKi 6.3 [27]
derenofylline Small molecule or natural product Click here for species-specific activity table Rn Antagonist 6.3 pKi 39
pKi 6.3 (Ki 5.01x10-7 M) [39]
SCH 58261 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.0 – 6.5 pKi 7,36
pKi 6.0 – 6.5 [7,36]
KF26777 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.2 pKi 64
pKi 6.2 (Ki 6.2x10-7 M) [64]
FK-453 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.0 pKi 36
pKi 6.0 (Ki 9.8x10-7 M) [36]
alloxazine Small molecule or natural product Hs Antagonist 5.7 – 6.3 pKi 37-38
pKi 5.7 – 6.3 [37-38]
preladenant Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Antagonist <6.0 pKi 56
pKi <6.0 (Ki >1x10-6 M) [56]
MRE 3008F20 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 5.7 – 5.8 pKi 36,73-74
pKi 5.7 – 5.8 [36,73-74]
PSB-10 Small molecule or natural product Mm Antagonist 5.7 pKi 57
pKi 5.7 (Ki 2.1x10-6 M) [57]
PSB-11 Small molecule or natural product Mm Antagonist 5.7 pKi 57
pKi 5.7 (Ki 2.1x10-6 M) [57]
derenofylline Small molecule or natural product Click here for species-specific activity table Hs Antagonist 5.4 pKi 39
pKi 5.4 (Ki 3.981x10-6 M) [39]
pentoxifylline Small molecule or natural product Approved drug Ligand has a PDB structure Hs Antagonist 5.3 pKi 44
pKi 5.3 (Ki 5.18x10-6 M) [44]
MSX-2 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 5.0 – 5.5 pKi 66,68
pKi 5.0 – 5.5 (Ki 1x10-5 – 2.9x10-6 M) [66,68]
theophylline Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Mm Antagonist 5.3 pKi 4
pKi 5.3 (Ki 5.63x10-6 M) [4]
CSC Small molecule or natural product Click here for species-specific activity table Rn Antagonist 5.1 pKi 16
pKi 5.1 (Ki 8.2x10-6 M) [16]
MRS1191 Small molecule or natural product Click here for species-specific activity table Hs Antagonist <5.0 pKi 49
pKi <5.0 (Ki >1x10-5 M) [49]
MRS1523 Small molecule or natural product Click here for species-specific activity table Hs Antagonist <5.0 pKi 49
pKi <5.0 (Ki >1x10-5 M) [49]
MRS1523 Small molecule or natural product Click here for species-specific activity table Mm Antagonist <5.0 pKi 49
pKi <5.0 (Ki >1x10-5 M) [49]
SCH442416 Small molecule or natural product Click here for species-specific activity table Hs Antagonist <5.0 pKi 36
pKi <5.0 (Ki >1x10-5 M) [36]
istradefylline Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist <5.0 pKi 31
pKi <5.0 (Ki >1x10-5 M) [31]
caffeine Small molecule or natural product Approved drug Ligand has a PDB structure Mm Antagonist 4.9 pKi 12
pKi 4.9 (Ki 1.3x10-5 M) [12]
caffeine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 4.5 – 5.0 pKi 6,10,44
pKi 4.5 – 5.0 (Ki 3.38x10-5 – 1.04x10-5 M) [6,10,44]
theophylline Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Antagonist 4.1 – 5.0 pKi 6,27,44,73
pKi 4.1 – 5.0 (Ki 7.4x10-5 – 9.07x10-6 M) [6,27,44,73]
caffeine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Rn Antagonist 4.5 pKi 12
pKi 4.5 (Ki 3x10-5 M) [12]
BAY-545 Small molecule or natural product Rn Antagonist 6.6 pIC50 35
pIC50 6.6 (IC50 2.8x10-7 M) [35]
BAY-545 Small molecule or natural product Mm Antagonist 6.4 pIC50 35
pIC50 6.4 (IC50 4x10-7 M) [35]
View species-specific antagonist tables
Antagonist Comments
pKi values for istradefylline relating to human targets are derived from unpublished data (Müller et al).
Immunopharmacology Comments
A2B receptor is discussed in this immuno-oncology review [1].
Cell Type Associations
Immuno Cell Type:  T cells
Cell Ontology Term:   CD4-positive, alpha-beta T cell (CL:0000624)
CD8-positive, alpha-beta T cell (CL:0000625)
type I NK T cell (CL:0000921)
Comment:  An anti-A2B receptor antibody shows expression in CD4+ and CD8+ T-cell subpopulations. More than 95% of Jurkat T cells were shown to be A2B receptor positive. A2B receptor is expressed by mouse iNKT cells.
References:  55,59
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
Comment:  A2B receptor is expressed by LAD2 mast cells at the mRNA and protein levels. Flow cytometry of permeabilised cells detected receptor protein in intracellular pools. By mRNA expression level, the A2A receptor was the most abundantly expressed of the four adenosine receptor subtypes (A2A > A2B > A3; A1 mRNA not detected).
References:  3
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002882 positive regulation of chronic inflammatory response to non-antigenic stimulus IEA
GO:0043306 positive regulation of mast cell degranulation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002882 positive regulation of chronic inflammatory response to non-antigenic stimulus IEA
GO:0043306 positive regulation of mast cell degranulation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0010575 positive regulation of vascular endothelial growth factor production IEA
GO:0032722 positive regulation of chemokine production IEA
GO:0032755 positive regulation of interleukin-6 production IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0032722 positive regulation of chemokine production IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0043306 positive regulation of mast cell degranulation IEA
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gs family Adenylate cyclase stimulation
References:  26,50
Secondary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
References:  26,50
Tissue Distribution Click here for help
Low levels found in the brain, heart, kidney and lung.
Species:  Human
Technique:  Northern blotting.
References:  65
Jejunum, ileum, colon.
Species:  Human
Technique:  RT-PCR.
References:  15
Bronchial smooth muscle cells.
Species:  Human
Technique:  RT-PCR.
References:  82
Large intestine, cecum, urinary bladder.
Species:  Human
Technique:  Northern blotting.
References:  69
Type II epithelial cells
Species:  Mouse
Technique:  Reporter gene
References:  14
Bone marrow-derived mast cells.
Species:  Mouse
Technique:  in situ hybridisation.
References:  52
Kidney: cortical tubular structures.
Species:  Mouse
Technique:  RNAse protection and RT-PCR.
References:  76
Hypophyseal pars tuberalis.
Species:  Rat
Technique:  in situ hybridisation.
References:  69
Kidney: cortical tubular structures.
Species:  Rat
Technique:  RNAse protection and RT-PCR.
References:  76
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Measurement of cAMP levels in HEK 293 cells transfected with the human A2B receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Stimulation of cAMP accumulation.
References:  50
Measurement of IP3 levels in HEK 293 cells transfected with the human A2B receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  PTX-insensitive increase in IP3 levels.
References:  50
Measurement of cAMP levels in COS-6M cells transfected with the rat A2B receptor.
Species:  Rat
Tissue:  COS-6M cells.
Response measured:  Stimulation of cAMP accumulation.
References:  69
Measurement of cAMP levels in CHO cells transfected with the human A2B receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of cAMP accumulation.
References:  11,63
Measurement of extracellular-regulated kinase 1/2 (ERK1/2) phosphorylation in CHO cells transfected with the human A1 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Phosphorylation of ER