Synonyms: EIDD-2801 | EIDD2801 | Lagevrio® | MK-4482 | MK4482
molnupiravir is an approved drug (UK (2021))
Compound class:
Synthetic organic
Comment: Molnupiravir (EIDD-2801, MK-4482) is an oral, broad-spectrum antiviral drug [1,8]. The proposed INN molnupiravir was released by the WHO in a special release to cover COVID-related therapeutics in October 2020 (Proposed INN: List 124-COVID-19). Chemically molnupiravir is the isopropylester prodrug of the ribonucleoside analogue β-D-N4-hydroxycytidine (EIDD-1931, or N-hydroxycytidine) [10-11]. Functionally, the active form of molnupiravir is incorporated into the virus' RNA by the viral RNA-dependent RNA polymerase (RdRp) during replication, which results in lethal mutagenesis [4]. Molnupiravir was originally designed by Emory University scientists to inhibit replication of influenza virus. It has subsequently been tested for activity against other RNA viruses, including pandemic SARS-CoV-2, SARS-CoV and MERS-CoV [14]. Molnupiravir was being progressed for COVID-19 in a collaboration between Ridgeback Biotherapeutics and Merck. In vivo therapeutic and prophylactic potential was reported in a peer reviewed manuscript in February 2021 [12].
There is concern that molnupiravir may induce mutations in the host, based on evidence from mammalian cell culture experiments [13] and using the Ames test (bacteria). |
|
Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (UK (2021)) |
Is prodrug? | Yes |
Active form | β-D-N4-hydroxycytidine |
Synonyms |
EIDD-2801 | EIDD2801 | Lagevrio® | MK-4482 | MK4482 |
Database Links | |
CAS Registry No. | 2349386-89-4 (source: WHO INN record) |
DrugCentral Ligand | 5377 |
GtoPdb PubChem SID | 405067330 |
PubChem CID | 145996610 |
RCSB PDB Ligand | XMO |
Search Google for chemical match using the InChIKey | HTNPEHXGEKVIHG-QCNRFFRDSA-N |
Search Google for chemicals with the same backbone | HTNPEHXGEKVIHG |
UniChem Compound Search for chemical match using the InChIKey | HTNPEHXGEKVIHG-QCNRFFRDSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | HTNPEHXGEKVIHG-QCNRFFRDSA-N |