grassystatin A [Ligand Id: 8674] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL567893 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5028] [GtoPdb: 1658] [UniProtKB: O14672] | ||||||||
| ChEMBL | Inhibition of ADAM10 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of ADAM10 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Inhibition of TACE after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of TACE | B | 5.91 | pIC50 | 1230 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ADAM9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5982] [GtoPdb: 1657] [UniProtKB: Q13443] | ||||||||
| ChEMBL | Inhibition of ADAM9 | B | 4.34 | pIC50 | 46100 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of ADAM9 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| ChEMBL | Inhibition of ACE1 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] | ||||||||
| ChEMBL | Inhibition of BACE1 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of BACE1 by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 10749-10765 [PMID:23181502] |
| calpain 1/Calpain 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3891] [GtoPdb: 2336] [UniProtKB: P07384] | ||||||||
| ChEMBL | Inhibition of calpain 1 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] | ||||||||
| ChEMBL | Inhibition of caspase 1 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 10/Caspase-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5037] [GtoPdb: 1626] [UniProtKB: Q92851] | ||||||||
| ChEMBL | Inhibition of caspase 10 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 14/Caspase-14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5991] [GtoPdb: 1627] [UniProtKB: P31944] | ||||||||
| GtoPdb | - | - | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-47 [PMID:19715320] |
| ChEMBL | Inhibition of caspase 14 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 2/Caspase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4884] [GtoPdb: 1618] [UniProtKB: P42575] | ||||||||
| ChEMBL | Inhibition of caspase 2 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574] | ||||||||
| ChEMBL | Inhibition of caspase 3 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 4/Caspase-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2226] [GtoPdb: 1620] [UniProtKB: P49662] | ||||||||
| ChEMBL | Inhibition of caspase 4 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 4/Caspase-4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075276] [GtoPdb: 1620] [UniProtKB: P70343] | ||||||||
| ChEMBL | Inhibition of mouse caspase 11 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 5/Caspase-5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3131] [GtoPdb: 1621] [UniProtKB: P51878] | ||||||||
| ChEMBL | Inhibition of caspase 5 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 6/Caspase-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308] [GtoPdb: 1622] [UniProtKB: P55212] | ||||||||
| ChEMBL | Inhibition of caspase 6 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 7/Caspase-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3468] [GtoPdb: 1623] [UniProtKB: P55210] | ||||||||
| ChEMBL | Inhibition of caspase 7 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 8/Caspase-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790] | ||||||||
| ChEMBL | Inhibition of caspase 8 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 9/Caspase-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2273] [GtoPdb: 1625] [UniProtKB: P55211] | ||||||||
| ChEMBL | Inhibition of caspase 9 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibition of cathepsin B after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] | ||||||||
| ChEMBL | Inhibition of cathepsin D after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin D in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin D in human MCF7 cells by fluorescence assay | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin D by fluorescence assay | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2012) 55: 10749-10765 [PMID:23181502] |
| ChEMBL | Inhibition of cathepsin D using MCA-KPILFFRLK(Dnp)-D-R-NH2 as substrate incubated for 10 to 15 mins prior to substrate addition measured every 5 min for 2 hrs by fluorometry | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2012) 20: 4774-4780 [PMID:22748705] |
| ChEMBL | Inhibition of cathepsin D | B | 7.58 | pIC50 | 26.5 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| GtoPdb | - | - | 7.58 | pIC50 | 26.5 | nM | IC50 | J Med Chem (2009) 52: 5732-47 [PMID:19715320] |
| ChEMBL | Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 15 mins followed by substrate addition measured at 5 mins interval for 120 mins by fluorescence assay | B | 7.59 | pIC50 | 26 | nM | IC50 | J Nat Prod (2017) 80: 2969-2986 [PMID:29087712] |
| cathepsin E/Cathepsin E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3092] [GtoPdb: 2346] [UniProtKB: P14091] | ||||||||
| ChEMBL | Inhibition of cathepsin E after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin E in human MCF7 cells by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin E in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of recombinant human C-terminal His10-tagged cathepsin E (Gln18 to Pro396 residues) using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 15 mins followed by substrate addition measured at 5 mins interval for 120 mins by fluorescence assay | B | 9.05 | pIC50 | 0.9 | nM | IC50 | J Nat Prod (2017) 80: 2969-2986 [PMID:29087712] |
| GtoPdb | - | - | 9.05 | pIC50 | 0.89 | nM | IC50 | J Med Chem (2009) 52: 5732-47 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin E | B | 9.05 | pIC50 | 0.89 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin E by fluorescence assay | B | 9.1 | pIC50 | 0.8 | nM | IC50 | J Med Chem (2012) 55: 10749-10765 [PMID:23181502] |
| ChEMBL | Inhibition of cathepsin E using MCA-KPILFFRLK(Dnp)-D-R-NH2 as substrate incubated for 10 to 15 mins prior to substrate addition measured every 5 min for 2 hrs by fluorometry | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Bioorg Med Chem (2012) 20: 4774-4780 [PMID:22748705] |
| cathepsin H/Cathepsin H in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2225] [GtoPdb: 2349] [UniProtKB: P09668] | ||||||||
| ChEMBL | Inhibition of cathepsin H after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] | ||||||||
| ChEMBL | Inhibition of cathepsin K after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin X after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin V/Cathepsin L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3272] [GtoPdb: 2352] [UniProtKB: O60911] | ||||||||
| ChEMBL | Inhibition of cathepsin V after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774] | ||||||||
| ChEMBL | Inhibition of cathepsin S after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin Z/Cathepsin Z in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4160] [GtoPdb: 2354] [UniProtKB: Q9UBR2] | ||||||||
| ChEMBL | Inhibition of cathepsin Z after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| chymase 1/Chymase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4068] [GtoPdb: 2340] [UniProtKB: P23946] | ||||||||
| ChEMBL | Inhibition of chymase after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] | ||||||||
| ChEMBL | Inhibition of factor 10a after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| coagulation factor XI/Coagulation factor XI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2820] [GtoPdb: 2360] [UniProtKB: P03951] | ||||||||
| ChEMBL | Inhibition of factor 11a after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin C/Dipeptidyl peptidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634] | ||||||||
| ChEMBL | Inhibition of cathepsin C after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] | ||||||||
| ChEMBL | Inhibition of DPP4 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2] | ||||||||
| ChEMBL | Inhibition of DPP9 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1] | ||||||||
| ChEMBL | Inhibition of DPP8 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Elastase 1 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3517] [UniProtKB: P00772] | ||||||||
| ChEMBL | Inhibition of porcine pancreatic elastase after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| kallikrein related peptidase 4/Kallikrein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4446] [GtoPdb: 2374] [UniProtKB: Q9Y5K2] | ||||||||
| ChEMBL | Inhibition of kallikrein 4 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| kallikrein related peptidase 5/Kallikrein 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4447] [GtoPdb: 2375] [UniProtKB: Q9Y337] | ||||||||
| ChEMBL | Inhibition of kallikrein 5 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| kallikrein related peptidase 8/Kallikrein 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4812] [GtoPdb: 2378] [UniProtKB: O60259] | ||||||||
| ChEMBL | Inhibition of kallikrein 8 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of MMP1 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP10/Matrix metalloproteinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4270] [GtoPdb: 1634] [UniProtKB: P09238] | ||||||||
| ChEMBL | Inhibition of MMP10 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP11/Matrix metalloproteinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2867] [GtoPdb: 1635] [UniProtKB: P24347] | ||||||||
| ChEMBL | Inhibition of MMP11 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP12/Matrix metalloproteinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4393] [GtoPdb: 1636] [UniProtKB: P39900] | ||||||||
| ChEMBL | Inhibition of MMP12 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of MMP13 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of MMP14 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of MMP2 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of MMP3 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Inhibition of MMP7 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Inhibition of MMP8 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of MMP9 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Papain in Carica papaya (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4779] [UniProtKB: P00784] | ||||||||
| ChEMBL | Inhibition of papaya papain after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| kallikrein B1/Plasma kallikrein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952] | ||||||||
| ChEMBL | Inhibition of plasma kallikrein after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] | ||||||||
| ChEMBL | Inhibition of human plasmin after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797] | ||||||||
| ChEMBL | Inhibition of human renin after 10 to 15 mins by fluorescence assay | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
| ChEMBL | Inhibition of thrombin alpha after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760] | ||||||||
| ChEMBL | Inhibition of bovine pancreatic trypsin after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| tryptase alpha/beta 1/Tryptase beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2617] [GtoPdb: 2424] [UniProtKB: Q15661] | ||||||||
| ChEMBL | Inhibition of tryptase beta2 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| tryptase gamma 1/Tryptase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4955] [GtoPdb: 2425] [UniProtKB: Q9NRR2] | ||||||||
| ChEMBL | Inhibition of human lung tryptase gamma1 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749] | ||||||||
| ChEMBL | Inhibition of urokinase after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| protein C, inactivator of coagulation factors Va and VIIIa/Vitamin K-dependent protein C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4444] [GtoPdb: 2396] [UniProtKB: P04070] | ||||||||
| ChEMBL | Inhibition of activated protein C after 10 to 15 mins by fluorescence assay in presence of 50% glycine | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
