Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	461	2q14.3	PROC	protein C, inactivator of coagulation factors Va and VIIIa
Mouse	-	460	18 B1	Proc	protein C
Rat	-	461	18p12	Proc	protein C, inactivator of coagulation factors Va and VIIIa

Previous and Unofficial Names

anticoagulant protein C | autoprothrombin IIA | PC | vitamin K-dependent protein C | blood coagulation factor XIV | protein C (inactivator of coagulation factors Va and VIIIa)

Database Links
Specialist databases
MEROPS	S01.218 (Hs)
Other databases
Alphafold	P04070 (Hs), P33587 (Mm), P31394 (Rn)
BRENDA	3.4.21.69
CATH/Gene3D	4.10.740.10
ChEMBL Target	CHEMBL4444 (Hs)
DrugBank Target	P04070 (Hs), P04070 (Hs), P04070 (Hs)
Ensembl Gene	ENSG00000115718 (Hs), ENSMUSG00000024386 (Mm), ENSRNOG00000014376 (Rn)
Entrez Gene	5624 (Hs), 19123 (Mm), 25268 (Rn)
Human Protein Atlas	ENSG00000115718 (Hs)
KEGG Enzyme	3.4.21.69
KEGG Gene	hsa:5624 (Hs), mmu:19123 (Mm), rno:25268 (Rn)
OMIM	612283 (Hs)
Orphanet	ORPHA118030 (Hs)
Pharos	P04070 (Hs)
RefSeq Nucleotide	NM_000312 (Hs), NM_001042768 (Mm), NM_001042767 (Mm), NM_008934 (Mm), NM_012803 (Rn)
RefSeq Protein	NP_000303 (Hs), NP_001036233 (Mm), NP_032960 (Mm), NP_001036232 (Mm), NP_036935 (Rn)
UniProtKB	P04070 (Hs), P33587 (Mm), P31394 (Rn)
Wikipedia	PROC (Hs)

Enzyme Reaction
EC Number: 3.4.21.69

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 37 [PMID: 24418773] Hs Inhibition 7.4 pKi 1 ⤷ pKi 7.4 (Ki 4x10-8 M) [1]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Thrombophilia due to protein C deficiency, autosomal dominant Synonyms: Hereditary thrombophilia due to congenital protein C deficiency [Orphanet: ORPHA745] Thrombophilia [Disease Ontology: DOID:2452] Disease Ontology: DOID:2452 OMIM: 176860 Orphanet: ORPHA745
Disease:  Thrombophilia due to protein C deficiency, autosomal recessive Synonyms: Hereditary thrombophilia due to congenital protein C deficiency [Orphanet: ORPHA745] Thrombophilia [Disease Ontology: DOID:2452] Disease Ontology: DOID:2452 OMIM: 612304 Orphanet: ORPHA745