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MMP8

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Target id: 1632

Nomenclature: MMP8

Family: M10: Matrix metallopeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 467 11q21-q22 MMP8 matrix metallopeptidase 8
Mouse - 465 9 A1 Mmp8 matrix metallopeptidase 8
Rat - 466 8q11 Mmp8 matrix metallopeptidase 8
Previous and Unofficial Names Click here for help
PMNL collagenase | neutrophil collagenease | Collagenase-2 | CLG1 | matrix metallopeptidase 8 (neutrophil collagenase)
Database Links Click here for help
Specialist databases
MEROPS M10.002 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.24.34

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
SL422 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.3 pKi 4
pKi 9.3 (Ki 5x10-10 M) [4]
ONO-4817 Small molecule or natural product Hs Inhibition 9.0 pKi 5
pKi 9.0 (Ki 1.1x10-9 M) [5]
CGS-27023A Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.1 pIC50 2
pIC50 8.1 (IC50 7.7x10-9 M) [2]
doxycycline Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 4.6 pIC50 3
pIC50 4.6 (IC50 2.6x10-5 M) [3]
Inhibitor Comments
SL422 is a broad-spectrum inhibitor of MMP enzymes [4].
Immunopharmacology Comments
MMP8 is included in GtoImmuPdb based on its potential protective role in asthma.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes
GO:0043312 neutrophil degranulation TAS
GO:0150077 regulation of neuroinflammatory response TAS
GO:0150078 positive regulation of neuroinflammatory response ISS
GO:1903978 regulation of microglial cell activation TAS
GO:1903980 positive regulation of microglial cell activation ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0043312 neutrophil degranulation TAS
GO:1903978 regulation of microglial cell activation TAS
GO:1903980 positive regulation of microglial cell activation ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0032693 negative regulation of interleukin-10 production ISS
GO:0032755 positive regulation of interleukin-6 production ISS
GO:1904469 positive regulation of tumor necrosis factor secretion ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0150077 regulation of neuroinflammatory response TAS
GO:0150078 positive regulation of neuroinflammatory response ISS
GO:1903978 regulation of microglial cell activation TAS
GO:1903980 positive regulation of microglial cell activation ISS
Immuno Disease Associations
Disease Name:  Asthma
Disease Synonyms:  no synonynms
Comment:  MMP8 plays a protective role in asthma by promoting the clearance of recruited neutrophils.
Disease X-refs:  Disease Ontology: DOID:2841
OMIM: 600807
References:  1

References

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1. Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noël A, Cataldo DD. (2005) Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J. Immunol., 175 (4): 2589-97. [PMID:16081833]

2. Nuti E, Casalini F, Santamaria S, Gabelloni P, Bendinelli S, Da Pozzo E, Costa B, Marinelli L, La Pietra V, Novellino E et al.. (2011) Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem, 46 (7): 2617-29. [PMID:21514700]

3. Sepper R, Konttinen YT, Ding Y, Takagi M, Sorsa T. (1995) Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease. Chest, 107 (6): 1641-7. [PMID:7781360]

4. Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL et al.. (2001) Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J. Med. Chem., 44 (16): 2636-60. [PMID:11472217]

5. Yamada A, Uegaki A, Nakamura T, Ogawa K. (2000) ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs. Inflamm. Res., 49 (4): 144-6. [PMID:10858013]

How to cite this page

M10: Matrix metallopeptidase: MMP8. Last modified on 19/04/2017. Accessed on 22/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1632.