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MMP7

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Target id: 1631

Nomenclature: MMP7

Family: M10: Matrix metallopeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 267 11q21-q22 MMP7 matrix metallopeptidase 7
Mouse - 267 9 A1 Mmp7 matrix metallopeptidase 7
Rat - 267 8q11 Mmp7 matrix metallopeptidase 7
Previous and Unofficial Names Click here for help
matrin | PUMP-1 protease | uterine metalloproteinase | MPMM | MAT | MPSL1 | matrix metallopeptidase 7 (matrilysin, uterine)
Database Links Click here for help
Specialist databases
MEROPS M10.008 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.24.23

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
doxycycline Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 4.1 pKd 2
pKd 4.1 (Kd 7.3x10-5 M) [2]
SL422 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.1 pKi 4
pKi 9.1 (Ki 8x10-10 M) [4]
RS 39066 Small molecule or natural product Primary target of this compound Hs Inhibition 9.6 pIC50 1
pIC50 9.6 (IC50 2.3x10-10 M) [1]
marimastat Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.8 pIC50 3
pIC50 7.8 (IC50 1.6x10-8 M) [3]
Inhibitor Comments
SL422 is a broad-spectrum inhibitor of MMP enzymes [4].

References

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1. Chen JJ, Zhang Y, Hammond S, Dewdney N, Ho T, Lin X, Browner MF, Castelhano AL. (1996) Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2′-P3′ amide bond isostere. Bioorg. Med. Chem. Lett., 6: 1601-1606.

2. García RA, Pantazatos DP, Gessner CR, Go KV, Woods Jr VL, Villarreal FJ. (2005) Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol. Pharmacol., 67 (4): 1128-36. [PMID:15665254]

3. Rasmussen HS, McCann PP. (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol. Ther., 75 (1): 69-75. [PMID:9364582]

4. Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL et al.. (2001) Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J. Med. Chem., 44 (16): 2636-60. [PMID:11472217]

How to cite this page

M10: Matrix metallopeptidase: MMP7. Last modified on 28/07/2020. Accessed on 22/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1631.