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Caspase 2

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Target id: 1618

Nomenclature: Caspase 2

Family: C14: Caspase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 452 7q34 CASP2 caspase 2
Mouse - 452 6 20.54 cM Casp2 caspase 2
Rat - 452 4q24 Casp2 caspase 2
Previous and Unofficial Names Click here for help
protein phosphatase 1, regulatory subunit 57 | protease ICH-1 | ICH1 | NEDD2 | neural precursor cell expressed developmentally down-regulated protein 2 | PPP1R57 | caspase 2, apoptosis-related cysteine peptidase
Database Links Click here for help
Specialist databases
MEROPS C14.006 (Hs)
Other databases
Alphafold P42575 (Hs), P29594 (Mm), P55215 (Rn)
BRENDA 3.4.22.55
ChEMBL Target CHEMBL4884 (Hs)
Ensembl Gene ENSG00000106144 (Hs), ENSMUSG00000029863 (Mm), ENSRNOG00000016707 (Rn)
Entrez Gene 835 (Hs), 12366 (Mm), 64314 (Rn)
Human Protein Atlas ENSG00000106144 (Hs)
KEGG Enzyme 3.4.22.55
KEGG Gene hsa:835 (Hs), mmu:12366 (Mm), rno:64314 (Rn)
OMIM 600639 (Hs)
Pharos P42575 (Hs)
RefSeq Nucleotide NM_032983 (Hs), NM_001224 (Hs), NM_032982 (Hs), NM_007610 (Mm), NM_022522 (Rn)
RefSeq Protein NP_116765 (Hs), NP_116764 (Hs), NP_001215 (Hs), NP_031636 (Mm), NP_071967 (Rn)
UniProtKB P42575 (Hs), P29594 (Mm), P55215 (Rn)
Wikipedia CASP2 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.22.55

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 4 [PMID: 12408711] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.0 pKi 1
⤷ pKi 6.0 (Ki 9.6x10-7 M) [1]
Z-VDVAD-FMK Peptide Hs Inhibition - - 2
⤷ [2]

References

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1. Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL et al.. (2002) Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem, 45 (23): 5005-22. [PMID:12408711]

2. Gamen S, Anel A, Pérez-Galán P, Lasierra P, Johnson D, Piñeiro A, Naval J. (2000) Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res, 258 (1): 223-35. [PMID:10912804]

How to cite this page

C14: Caspase: Caspase 2. Last modified on 22/07/2015. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1618.